Emergence of azole resistant-Aspergillus fumigatus infections during STAT3-deficiency

François Danion; Amélie Duréault; Cécile Gautier; Agathe Senechal; Florence Persat; Marie-Elisabeth Bougnoux; Claire Givel; Louis-Jean Couderc; Olivier Lortholary; Dea Garcia-Hermoso; Fanny Lanternier

doi:10.1099/jmm.0.001200

Journal articles

Emergence of azole resistant-Aspergillus fumigatus infections during STAT3-deficiency

François Danion ^{1, 2, 3} Amélie Duréault ¹ Cécile Gautier ^{4, 5} Agathe Senechal ⁶ Florence Persat ^{7, 8} Marie-Elisabeth Bougnoux ^{9, 10, 11} Claire Givel ^{12, 13, 14} Louis-Jean Couderc ^{15, 13, 14} Olivier Lortholary ^{1, 5, 10} Dea Garcia-Hermoso ⁵ Fanny Lanternier ^{1, 5, *}

* Corresponding author

1 Centre d'infectiologie Necker-Pasteur [CHU Necker]

2 Aspergillus

3 Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)

4 Institut Pasteur [Paris]

5 CNRMA - Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals

6 Hôpital Louis Pradel - Services de Pneumologie, Exploration Fonctionnelle Respiratoire et Cardiologie

7 Université de Lyon

8 IAI - Institut des Agents Infectieux [Lyon]

9 Unité de Parasitologie-Mycologie, Service de Microbiologie [Hôpital Necker-Enfants-Malades, Paris]

10 UP - Université de Paris

11 BPF - Biologie et Pathogénicité fongiques - Fungal Biology and Pathogenicity

12 Service de pneumologie [Hôpital Foch]

13 UPRES EA220

14 UVSQ Santé - Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil

15 Hôpital Foch [Suresnes]

Abstract : Introduction. Signal transducer and activator of transcription 3 (STAT3) deficiency is a rare primary immunodeficiency associated with increased susceptibility to bacterial and fungal infections, notably pulmonary aspergillosis. Aim. We describe the emergence of azole-resistant Aspergillus fumigatus infections in STAT3-deficient patients. Methodology. During a retrospective study of 13 pulmonary aspergillosis cases in STAT3-deficient patients conducted in France, we identified patients infected with azole-resistant A. fumigatus isolates.

Keywords : IA invasive aspergillosis MLP microsatellite length polymorphism STAT3 signal transducer and activator of transcription 3 STAT3-deficiency chronic mucocutaneous candidiasis CMC chronic cavitary pulmonary aspergillosis CCPA amphotericin B AmB allergic bronchopulmonary aspergillosis STAT3-deficiency. Abbreviations: ABPA resistance hyper-IgE syndrome azoles aspergillosis Aspergillus fumigatus

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Microbiology and Parasitology / Mycology

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Submitted on : Monday, May 10, 2021 - 2:26:29 PM
Last modification on : Wednesday, July 21, 2021 - 4:10:02 PM

Emergence of azole resistant-Aspergillus fumigatus infections during STAT3-deficiency

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Emergence of azole resistant-Aspergillus fumigatus infections during STAT3-deficiency

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