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Journal Articles Medical Mycology Year : 2020

Scedosporiosis/lomentosporiosis observational study (SOS): Clinical significance of Scedosporium species identification

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Laurence Maulin
  • Function : Author
Yves Leprince
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Berengere Gruson
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Youssef El-Samad
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Sophie Bayle
  • Function : Author
Cécile Jensen
  • Function : Author
Stéphanie Branger
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Grégoire Leclerc
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Laurent Hustache-Mathieu
  • Function : Author
Fabrice Larosa
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Frédéric Grenouillet
  • Function : Author
Diane Bouvry
  • Function : Author
Frédéric Mechai
  • Function : Author
Sophie Brun
  • Function : Author
Frédéric Villega
  • Function : Author
Hervé Dutronc
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Jean-François Velly
  • Function : Author
Laurence Delhaes
  • Function : Author
Frederic Gabriel
  • Function : Author
Nicolas Paleiron
  • Function : Author
Laurence Di Costanzo Pougnet
  • Function : Author
Anne de Tinteniac
  • Function : Author
Luc Quaesaet
  • Function : Author
Liana Carausu
  • Function : Author
Gaelle Guillerm
  • Function : Author
Lenaïg Le Clech
  • Function : Author
Gilles Nevez
Julie Bonhomme
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Cécile Molucon-Chabrot
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Jacques-Olivier Bay
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Céline Nourrisson
Philippe Poirier
Agnes Lefort
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Véronique Leflon-Guibout
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Catherine Cordonnier
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Nicolas Limal
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Françoise Botterel-Chartier
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Hôpital Henri Mondor
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Philippe Zann
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Benoit Roze
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Nicole Desbois
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Lelia Escaut
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Jean-François Papon
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Adela Angoulvant
Kamel Laribi
Pascale Penn
  • Function : Author
Pascal Turlure
  • Function : Author
Thomas Daix
Boris Melloni
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Bernard Bouteille
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Thomas Perpoint
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Florence Ader
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Marie Balsat
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Florence Persat
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Jean-Marie Forel
Valérie Moal
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Stéphane Ranque
Cristina Audoly
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Delphine Lancement
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Caroline Fritz
Joséphine Dorin
  • Function : Author
Marie Machouart
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David Boutoille
Jérémie Orain
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Delphine Horeau-Langlard
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Florent Morio
Olivier Moquet
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Viviane Queyrel-Moranne
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Lionel Mannone
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Pierre-Marie Roger
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Martine Gari-Toussaint
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Lilia Hasseine
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Giovanna Ingenuo
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Nicolas Durrleman
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Nina Arakelyan-Laboure
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Didier Poisson
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Marine Paul
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Frederic Pene
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André Paugam
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Valérie Zeller
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Beate Heym
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Romain Guillemain
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Yoann Prevot
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Eric Dannaoui
Pierre Frange
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Stéphane Blanche
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Felipe Suarez
Anne Scemla
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Romain Guery
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Olivier Lortholary
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Marie-Elisabeth Bougnoux
Thomas Similowski
Eric Caumes
Arnaud Fekkar
Ana Presedo
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Patricia Mariani
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Nicolas Engrand
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Flore Sicre de Fontbrune
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Philippe Herman
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Alexandre Alanio
  • Function : Author
Stéphane Bretagne
Rachel Brault
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Blandine Rammaert
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Catherine Kauffmann-Lacroix
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Alain Delmer
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Violaine Noel
  • Function : Author
Dominique Toubas
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Antoine Huguenin
  • Function : Author
Matthieu Revest
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  • IdRef : 120446855
Sorya Belaz
  • Function : Author
Jean-Pierre Gangneux
Céline Dieval
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Isabelle Degasne
  • Function : Author
Nicolas Traversier
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Claire Briere-Bellier
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Patrick Lutz
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Françoise Uettwiller
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Raoul Herbrecht
Valérie Letscher-Bru
Emilie Catherinot
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Louis-Jean Couderc
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Elizabeth Rivaud
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Pierre Cahen
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François Bissuel
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Muriel Alvarez
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Guillaume Martin-Blondel
Morgane Mourguet
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Emmanuelle Mouchon
  • Function : Author
Anne Huynh
  • Function : Author
Noémie Gadaud
  • Function : Author
Joelle Guitard
  • Function : Author
Xavier Iriart
  • Function : Author
  • PersonId : 994510
Sophie Cassaing
Christophe Joubert
  • Function : Author
Frédéric Janvier
  • Function : Author
Audrey Berric
  • Function : Author
Jacques Grill
  • Function : Author
Florence Pasquier
  • Function : Author
Stéphane de Botton
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Elisabeth Chachaty
  • Function : Author
Anne Boullié
  • Function : Author
Cécile Gautier
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Audrey Hessel
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Damien Hoinard
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Dorothée Raoux-Barbot
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The French Mycoses Study Group
  • Function : Author
  • PersonId : 1035501

Abstract

Scedosporiosis/lomentosporiosis is a devastating emerging fungal infection. Our objective was to describe the clinical pattern and to analyze whether taxonomic grouping of the species involved was supported by differences in terms of clinical presentations or outcomes. We retrospectively studied cases of invasive scedosporiosis in France from 2005 through 2017 based on isolates characterized by polyphasic approach. We recorded 90 cases, mainly related to Scedosporium apiospermum (n = 48), S. boydii/S. ellipsoideum (n = 20), and Lomentospora prolificans (n = 14). One-third of infections were disseminated, with unexpectedly high rates of cerebral (41%) and cardiovascular (31%) involvement. In light of recent Scedosporium taxonomic revisions, we aimed to study the clinical significance of Scedosporium species identification and report for the first time contrasting clinical presentations between infections caused S. apiospermum, which were associated with malignancies and cutaneous involvement in disseminated infections, and infections caused by S. boydii, which were associated with solid organ transplantation, cerebral infections, fungemia, and early death. The clinical presentation of L. prolificans also differed from that of other species, involving more neutropenic patients, breakthrough infections, fungemia, and disseminated infections. Neutropenia, dissemination, and lack of antifungal prescription were all associated with 3-month mortality. Our data support the distinction between S. apiospermum and S. boydii and between L. prolificans and Scedosporium sp. Our results also underline the importance of the workup to assess dissemination, including cardiovascular system and brain. Lay Summary Scedosporiosis/lomentosporiosis is a devastating emerging fungal infection. Our objective was to describe the clinical pattern and to analyze whether taxonomic grouping of the species involved was supported by differences in terms of clinical presentations or outcomes.
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Dates and versions

pasteur-03222501 , version 1 (10-05-2021)

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Didier Bronnimann, Dea Garcia-Hermoso, Françoise Dromer, Fanny Lanternier, Laurence Maulin, et al.. Scedosporiosis/lomentosporiosis observational study (SOS): Clinical significance of Scedosporium species identification. Medical Mycology, 2020, 59 (5), pp.486 - 497. ⟨10.1093/mmy/myaa086⟩. ⟨pasteur-03222501⟩
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