Scedosporiosis/lomentosporiosis observational study (SOS): Clinical significance of Scedosporium species identification
Didier Bronnimann
(1, 2, 3)
,
Dea Garcia-Hermoso
(4, 5)
,
Françoise Dromer
(4, 5)
,
Fanny Lanternier
(6, 4, 3, 5)
,
Laurence Maulin
,
Yves Leprince
,
Nathalie Brieu
(7)
,
Berengere Gruson
,
Youssef El-Samad
,
Taieb Chouaki
(8)
,
Sophie Bayle
,
Cécile Jensen
,
Stéphanie Branger
,
Grégoire Leclerc
,
Laurent Hustache-Mathieu
,
Fabrice Larosa
,
Frédéric Grenouillet
,
Diane Bouvry
,
Frédéric Mechai
,
Sophie Brun
,
Frédéric Villega
,
Hervé Dutronc
,
Jean-François Velly
,
Laurence Delhaes
,
Frederic Gabriel
,
Nicolas Paleiron
,
Laurence Di Costanzo Pougnet
,
Anne de Tinteniac
,
Luc Quaesaet
,
Liana Carausu
,
Gaelle Guillerm
,
Lenaïg Le Clech
,
Gilles Nevez
,
Julie Bonhomme
,
Cécile Molucon-Chabrot
,
Jacques-Olivier Bay
,
Céline Nourrisson
,
Philippe Poirier
,
Agnes Lefort
,
Véronique Leflon-Guibout
,
Catherine Cordonnier
,
Nicolas Limal
,
Françoise Botterel-Chartier
,
Hôpital Henri Mondor
,
Philippe Zann
,
Benoit Roze
,
Nicole Desbois
,
Lelia Escaut
,
Jean-François Papon
,
Adela Angoulvant
,
Kamel Laribi
,
Pascale Penn
,
Pascal Turlure
,
Thomas Daix
,
Boris Melloni
,
Bernard Bouteille
,
Thomas Perpoint
,
Florence Ader
,
Marie Balsat
,
Florence Persat
,
Jean-Marie Forel
,
Valérie Moal
,
Stéphane Ranque
,
Cristina Audoly
,
Delphine Lancement
,
Caroline Fritz
,
Joséphine Dorin
,
Marie Machouart
,
David Boutoille
,
Jérémie Orain
,
Delphine Horeau-Langlard
,
Florent Morio
,
Olivier Moquet
,
Viviane Queyrel-Moranne
,
Lionel Mannone
,
Pierre-Marie Roger
,
Martine Gari-Toussaint
,
Lilia Hasseine
,
Giovanna Ingenuo
,
Nicolas Durrleman
,
Nina Arakelyan-Laboure
,
Didier Poisson
,
Marine Paul
,
Frederic Pene
,
André Paugam
,
Valérie Zeller
,
Beate Heym
,
Romain Guillemain
,
Yoann Prevot
,
Eric Dannaoui
,
Pierre Frange
,
Stéphane Blanche
,
Felipe Suarez
,
Anne Scemla
,
Romain Guery
,
Olivier Lortholary
,
Marie-Elisabeth Bougnoux
,
Thomas Similowski
,
Eric Caumes
,
Arnaud Fekkar
,
Ana Presedo
,
Patricia Mariani
,
Nicolas Engrand
,
Flore Sicre de Fontbrune
,
Philippe Herman
,
Alexandre Alanio
,
Stéphane Bretagne
,
Rachel Brault
,
Blandine Rammaert
,
Catherine Kauffmann-Lacroix
,
Alain Delmer
,
Violaine Noel
,
Dominique Toubas
,
Antoine Huguenin
,
Matthieu Revest
,
Sorya Belaz
,
Jean-Pierre Gangneux
,
Céline Dieval
,
Isabelle Degasne
,
Nicolas Traversier
,
Claire Briere-Bellier
,
Patrick Lutz
,
Françoise Uettwiller
,
Raoul Herbrecht
,
Valérie Letscher-Bru
,
Emilie Catherinot
,
Louis-Jean Couderc
,
Elizabeth Rivaud
,
Pierre Cahen
,
François Bissuel
,
Muriel Alvarez
,
Guillaume Martin-Blondel
,
Morgane Mourguet
,
Emmanuelle Mouchon
,
Anne Huynh
,
Noémie Gadaud
,
Joelle Guitard
,
Xavier Iriart
,
Sophie Cassaing
,
Christophe Joubert
,
Frédéric Janvier
,
Audrey Berric
,
Jacques Grill
,
Florence Pasquier
,
Stéphane de Botton
,
Elisabeth Chachaty
,
Anne Boullié
,
Cécile Gautier
,
Audrey Hessel
,
Damien Hoinard
,
Dorothée Raoux-Barbot
,
The French Mycoses Study Group
1
CHU Necker - Enfants Malades [AP-HP]
2 Université Victor Segalen - Bordeaux 2
3 UPCité - Université Paris Cité
4 Mycologie moléculaire - Molecular Mycology
5 CNRMA - Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals
6 Centre d'infectiologie Necker-Pasteur [CHU Necker]
7 Centre Hospitalier du Pays d'Aix
8 CHU Amiens-Picardie
2 Université Victor Segalen - Bordeaux 2
3 UPCité - Université Paris Cité
4 Mycologie moléculaire - Molecular Mycology
5 CNRMA - Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals
6 Centre d'infectiologie Necker-Pasteur [CHU Necker]
7 Centre Hospitalier du Pays d'Aix
8 CHU Amiens-Picardie
Françoise Dromer
- Function : Author
- PersonId : 182926
- IdHAL : francoise-dromer
- ORCID : 0000-0003-1671-1475
- IdRef : 074496492
Fanny Lanternier
Connectez-vous pour contacter l'auteur
- Function : Correspondent author
- PersonId : 1068224
Connectez-vous pour contacter l'auteur
Laurence Maulin
- Function : Author
Yves Leprince
- Function : Author
Berengere Gruson
- Function : Author
Youssef El-Samad
- Function : Author
Sophie Bayle
- Function : Author
Cécile Jensen
- Function : Author
Stéphanie Branger
- Function : Author
Grégoire Leclerc
- Function : Author
Laurent Hustache-Mathieu
- Function : Author
Fabrice Larosa
- Function : Author
Frédéric Grenouillet
- Function : Author
Diane Bouvry
- Function : Author
Frédéric Mechai
- Function : Author
Sophie Brun
- Function : Author
Frédéric Villega
- Function : Author
Hervé Dutronc
- Function : Author
Jean-François Velly
- Function : Author
Laurence Delhaes
- Function : Author
Frederic Gabriel
- Function : Author
Nicolas Paleiron
- Function : Author
Laurence Di Costanzo Pougnet
- Function : Author
Anne de Tinteniac
- Function : Author
Luc Quaesaet
- Function : Author
Liana Carausu
- Function : Author
Gaelle Guillerm
- Function : Author
Lenaïg Le Clech
- Function : Author
Gilles Nevez
- Function : Author
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- ORCID : 0000-0001-5888-6017
Julie Bonhomme
- Function : Author
Cécile Molucon-Chabrot
- Function : Author
Jacques-Olivier Bay
- Function : Author
Céline Nourrisson
- Function : Author
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Philippe Poirier
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Agnes Lefort
- Function : Author
Véronique Leflon-Guibout
- Function : Author
Catherine Cordonnier
- Function : Author
Nicolas Limal
- Function : Author
Françoise Botterel-Chartier
- Function : Author
Hôpital Henri Mondor
- Function : Author
Philippe Zann
- Function : Author
Benoit Roze
- Function : Author
Nicole Desbois
- Function : Author
Lelia Escaut
- Function : Author
Jean-François Papon
- Function : Author
Adela Angoulvant
- Function : Author
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Kamel Laribi
- Function : Author
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Pascale Penn
- Function : Author
Pascal Turlure
- Function : Author
Thomas Daix
- Function : Author
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Boris Melloni
- Function : Author
Bernard Bouteille
- Function : Author
Thomas Perpoint
- Function : Author
Florence Ader
- Function : Author
Marie Balsat
- Function : Author
Florence Persat
- Function : Author
Jean-Marie Forel
- Function : Author
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Valérie Moal
- Function : Author
Stéphane Ranque
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Cristina Audoly
- Function : Author
Delphine Lancement
- Function : Author
Caroline Fritz
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Joséphine Dorin
- Function : Author
Marie Machouart
- Function : Author
David Boutoille
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Jérémie Orain
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Delphine Horeau-Langlard
- Function : Author
Florent Morio
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Olivier Moquet
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Viviane Queyrel-Moranne
- Function : Author
Lionel Mannone
- Function : Author
Pierre-Marie Roger
- Function : Author
Martine Gari-Toussaint
- Function : Author
Lilia Hasseine
- Function : Author
Giovanna Ingenuo
- Function : Author
Nicolas Durrleman
- Function : Author
Nina Arakelyan-Laboure
- Function : Author
Didier Poisson
- Function : Author
Marine Paul
- Function : Author
Frederic Pene
- Function : Author
André Paugam
- Function : Author
Valérie Zeller
- Function : Author
Beate Heym
- Function : Author
Romain Guillemain
- Function : Author
Yoann Prevot
- Function : Author
Eric Dannaoui
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Pierre Frange
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Stéphane Blanche
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Felipe Suarez
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Anne Scemla
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Romain Guery
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Olivier Lortholary
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Marie-Elisabeth Bougnoux
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Thomas Similowski
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Eric Caumes
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Arnaud Fekkar
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Ana Presedo
- Function : Author
Patricia Mariani
- Function : Author
Nicolas Engrand
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Flore Sicre de Fontbrune
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Philippe Herman
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Alexandre Alanio
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Stéphane Bretagne
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Rachel Brault
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Blandine Rammaert
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Catherine Kauffmann-Lacroix
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Alain Delmer
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Violaine Noel
- Function : Author
Dominique Toubas
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Antoine Huguenin
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Matthieu Revest
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Sorya Belaz
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Jean-Pierre Gangneux
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Céline Dieval
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Isabelle Degasne
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Nicolas Traversier
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Claire Briere-Bellier
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Patrick Lutz
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Françoise Uettwiller
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Raoul Herbrecht
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Valérie Letscher-Bru
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Emilie Catherinot
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Louis-Jean Couderc
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Elizabeth Rivaud
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Pierre Cahen
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François Bissuel
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Muriel Alvarez
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Guillaume Martin-Blondel
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Morgane Mourguet
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Emmanuelle Mouchon
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Anne Huynh
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Noémie Gadaud
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Joelle Guitard
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Xavier Iriart
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Sophie Cassaing
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Christophe Joubert
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Frédéric Janvier
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Audrey Berric
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Jacques Grill
- Function : Author
Florence Pasquier
- Function : Author
Stéphane de Botton
- Function : Author
Elisabeth Chachaty
- Function : Author
Anne Boullié
- Function : Author
Cécile Gautier
- Function : Author
Audrey Hessel
- Function : Author
Damien Hoinard
- Function : Author
Dorothée Raoux-Barbot
- Function : Author
The French Mycoses Study Group
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Abstract
Scedosporiosis/lomentosporiosis is a devastating emerging fungal infection. Our objective was to describe the clinical pattern and to analyze whether taxonomic grouping of the species involved was supported by differences in terms of clinical presentations or outcomes. We retrospectively studied cases of invasive scedosporiosis in France from 2005 through 2017 based on isolates characterized by polyphasic approach. We recorded 90 cases, mainly related to Scedosporium apiospermum (n = 48), S. boydii/S. ellipsoideum (n = 20), and Lomentospora prolificans (n = 14). One-third of infections were disseminated, with unexpectedly high rates of cerebral (41%) and cardiovascular (31%) involvement. In light of recent Scedosporium taxonomic revisions, we aimed to study the clinical significance of Scedosporium species identification and report for the first time contrasting clinical presentations between infections caused S. apiospermum, which were associated with malignancies and cutaneous involvement in disseminated infections, and infections caused by S. boydii, which were associated with solid organ transplantation, cerebral infections, fungemia, and early death. The clinical presentation of L. prolificans also differed from that of other species, involving more neutropenic patients, breakthrough infections, fungemia, and disseminated infections. Neutropenia, dissemination, and lack of antifungal prescription were all associated with 3-month mortality. Our data support the distinction between S. apiospermum and S. boydii and between L. prolificans and Scedosporium sp. Our results also underline the importance of the workup to assess dissemination, including cardiovascular system and brain. Lay Summary Scedosporiosis/lomentosporiosis is a devastating emerging fungal infection. Our objective was to describe the clinical pattern and to analyze whether taxonomic grouping of the species involved was supported by differences in terms of clinical presentations or outcomes.
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