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The impact of space and time on the functional output of the nucleus

Abstract : Over the past two decades, it has become clear that the multi-scale spatial and temporal organization of the genome has important implications for nuclear function. This chapter centers on insights gained from recent advances in light microscopy on our understanding of transcription. Particular focus is given to the genomic scales where most functional interactions occur, namely kb-Mb. We discuss the relevant spatial and temporal scales that shape nuclear order and their consequences on regulatory components and function. The emerging picture is that spatiotemporal constraints increase the complexity in transcriptional regulation. This brings new challenges to the fore, such as uncertainty about how information travels from factors through the genome and space to generate a functional output.
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Contributor : Thomas Gregor Connect in order to contact the contributor
Submitted on : Wednesday, October 13, 2021 - 10:48:24 AM
Last modification on : Friday, August 5, 2022 - 12:03:04 PM
Long-term archiving on: : Friday, January 14, 2022 - 6:41:41 PM


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Distributed under a Creative Commons Attribution - NonCommercial 4.0 International License


  • HAL Id : pasteur-03216312, version 1


Marcelo Nollmann, Isma Bennabi, Markus Götz, Thomas Gregor. The impact of space and time on the functional output of the nucleus. Ana Pombo; Martin Hetzer; Tom Misteli. Nucleus, 2nd ed., Cold Spring Harbor laboratory press, 2021, 978-1-621823-89-6. ⟨pasteur-03216312⟩



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