Trading bits in the readout from a genetic network - Archive ouverte HAL Access content directly
Journal Articles Proceedings of the National Academy of Sciences of the United States of America Year : 2021

Trading bits in the readout from a genetic network

(1) , (2, 1) , (3, 1) , (4) , (1, 5)
1
2
3
4
5

Abstract

In genetic networks, information of relevance to the organism is represented by the concentrations of transcription factor molecules. In order to extract this information the cell must effectively "measure"' these concentrations, but there are physical limits to the precision of these measurements. We explore this trading between bits of precision in measuring concentration and bits of relevant information that can be extracted, using the gap gene network in the early fly embryo as an example. We argue that cells in the embryo can extract all the available information about their position, but only if the concentration measurements approach the physical limits to information capacity. These limits necessitate the observed proliferation of enhancer elements with sensitivities to combinations of transcription factors, but fine tuning of the parameters of these multiple enhancers is not required.
Fichier principal
Vignette du fichier
bauer+al_210831.pdf (3.59 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

pasteur-03216308 , version 1 (03-05-2021)
pasteur-03216308 , version 2 (13-12-2022)

Licence

Attribution - CC BY 4.0

Identifiers

Cite

Marianne Bauer, Mariela D Petkova, Thomas Gregor, Eric F Wieschaus, William Bialek. Trading bits in the readout from a genetic network. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (46), pp.e2109011118. ⟨10.1073/pnas.2109011118⟩. ⟨pasteur-03216308v2⟩
23 View
22 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More