Involvement of amyloid proteins in the formation of biofilms in the pathogenic yeast Candida albicans

Thierry Mourer (1) , Mennat El Ghalid (1) , Christophe D'Enfert (1) , Sophie Bachellier-Bassi (1)

1 BPF - Biologie et Pathogénicité fongiques - Fungal Biology and Pathogenicity

Candida species represent a major fungal threat for human health. Within the Candida genus, the yeast Candida albicans is the most frequently incriminated species during episodes of candidiasis or candidemia. Biofilm formation is used by C. albicans to produce a microbial community that is important in an infectious context. The cell wall, the most superficial cellular compartment, is of paramount importance regarding the establishment of biofilms. C. albicans cell wall contains proteins with amyloid properties that are necessary for biofilm formation due to their adhesion properties. This review focuses on these amyloid proteins during biofilm formation in the yeast C. albicans.

Keywords: Human fungal pathogen; Candida albicans; biofilm; amyloid proteins; adhesion; cell wall

Domains: Life Sciences [q-bio]

Thierry Mourer, Mennat El Ghalid, Christophe D'Enfert, Sophie Bachellier-Bassi. Involvement of amyloid proteins in the formation of biofilms in the pathogenic yeast Candida albicans. Research in Microbiology, 2021, pp.103813. ⟨10.1016/j.resmic.2021.103813⟩. ⟨pasteur-03209970v2⟩