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Persistent risk of adult T-cell leukemia/lymphoma after neonatal HTLV-1 infection through exchange transfusion

Eric Oksenhendler 1 Jocelyn Turpin 2 Raphael Lhote 1 Olivier Cassar 3 Jean-Michel Cayuela 4, 5 Claire Fieschi 1 Lionel Galicier 1 Veronique Meignin 1 Charles Bangham 2 Antoine Gessain 3
1 AP-HP - Hopital Saint-Louis [AP-HP]
2 Imperial College London
3 EPVO (UMR_3569 / U-Pasteur_3) - Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology
4 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
5 (EA_3518) - Recherche clinique appliquée à l'hématologie
Abstract : A 36-year-old Caucasian male presented with adult T-cell leukemia/lymphoma (ATL). HTLV-1 contamination was attributed to a neonatal exchange transfusion. Remission was achieved but 11 years later he presented with symptoms suggesting ATL relapse. Molecular studies of T-cell clonality and virus integration sites revealed a clonal disease, distinct from the first tumor.
Keywords : Transfusion HTLV-1 Adult T-cell leukemia/lymphoma
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Journal articles
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03208072
Contributor : Olivier Cassar <>
Submitted on : Monday, April 26, 2021 - 12:03:26 PM
Last modification on : Friday, June 4, 2021 - 4:54:02 PM

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PASTEUR | CNRS | UP-SCIENCES | UP-SANTE

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Eric Oksenhendler, Jocelyn Turpin, Raphael Lhote, Olivier Cassar, Jean-Michel Cayuela, et al.. Persistent risk of adult T-cell leukemia/lymphoma after neonatal HTLV-1 infection through exchange transfusion. International Journal of Hematology, Springer Verlag, 2017, 105 (6), pp.859-862. ⟨10.1007/s12185-016-2174-0⟩. ⟨pasteur-03208072⟩

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