Persistent risk of adult T-cell leukemia/lymphoma after neonatal HTLV-1 infection through exchange transfusion

Eric Oksenhendler (1) , Jocelyn Turpin (2) , Raphael Lhote (1) , Olivier Cassar (3) , Jean-Michel Cayuela (4, 5) , Claire Fieschi (1) , Lionel Galicier (1) , Veronique Meignin (1) , Charles Bangham (2) , Antoine Gessain (3)

1 AP-HP - Hopital Saint-Louis [AP-HP]
2 Imperial College London
3 EPVO (UMR_3569 / U-Pasteur_3) - Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology
4 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
5 URP_3518 - Recherche clinique appliquée à l'hématologie

A 36-year-old Caucasian male presented with adult T-cell leukemia/lymphoma (ATL). HTLV-1 contamination was attributed to a neonatal exchange transfusion. Remission was achieved but 11 years later he presented with symptoms suggesting ATL relapse. Molecular studies of T-cell clonality and virus integration sites revealed a clonal disease, distinct from the first tumor.

Keywords: Adult T-cell leukemia/lymphoma; HTLV-1; Transfusion

Domains: Life Sciences [q-bio]

Eric Oksenhendler, Jocelyn Turpin, Raphael Lhote, Olivier Cassar, Jean-Michel Cayuela, et al.. Persistent risk of adult T-cell leukemia/lymphoma after neonatal HTLV-1 infection through exchange transfusion. International Journal of Hematology, 2017, 105 (6), pp.859-862. ⟨10.1007/s12185-016-2174-0⟩. ⟨pasteur-03208072⟩