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Multiple recombinant events in human T-cell Leukemia virus Type 1: complete sequences of recombinant African strains

Abstract : Africa is the largest endemic area for HTLV-1, with many molecular genotypes. We previously demonstrated that some strains from North Africa (a-NA clade) originated from a recombinant event between Senegalese and West African strains. A series of 52 new HTLV-1 strains from 13 North and West African countries were sequenced in the LTR region and/or a env gene fragment. Four samples from French Guyanese of African origin were also added. Furthermore, 7 complete sequences from different genotypes were characterized. Phylogenetic analyses showed that most of the new African strains belong to the Cosmopolitan a-genotype. Ten new strains from the a-NA clade were found in Morocco, Western Sahara, Mali, Guinea, Côte d'Ivoire and Ghana. A new a-G-Rec clade, which arose from a distinct recombination event between Senegalese and West African strains, was identified in Guinea and Ghana. The complete sequences suggest that recombination occur in the LTR as well as the env/pol region of the genome, thus a-NA and a-G-Rec strains have a mosaic profile with genetic segments from either a-WA or a-Sen strains. Our work demonstrates that recombination in HTLV-1 may not be as rare an event as previously proposed.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03208018
Contributor : Olivier Cassar <>
Submitted on : Monday, April 26, 2021 - 11:41:07 AM
Last modification on : Friday, June 11, 2021 - 2:48:02 PM

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Olivier Cassar, Alexandra Desrames, Ambroise Marçais, Olivier Gout, Graham Taylor, et al.. Multiple recombinant events in human T-cell Leukemia virus Type 1: complete sequences of recombinant African strains. Emerging microbes & infections, Earliest : Springer-Nature ; Latest : Taylor & Francis, 2020, 9 (1), pp.913-923. ⟨10.1080/22221751.2020.1752117⟩. ⟨pasteur-03208018⟩

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