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SARS-CoV-2 viral dynamics in non-human primates

Antonio Gonçalves 1, 2, * Pauline Maisonnasse 3 Flora Donati 4, 5 Mélanie Albert 5 Sylvie Behillil 4, 5 Vanessa Contreras 3 Thibaut Naninck 3 Romain Marlin 3 Caroline Solas 6 Andres Pizzorno 7 Julien Lemaitre 3 Nidhal Kahlaoui 3 Olivier Terrier 7, 8 Raphael Ho Tsong Fang 3 Vincent Enouf 5, 4, 9 Nathalie Dereuddre-Bosquet 3 Angela Brisebarre 5, 4 Franck Touret 6 Catherine Chapon 3 Bruno Hoen 10 Bruno Lina 7, 11 Manuel Rosa Calatrava 7 Xavier de Lamballerie 6 France Mentré 1 Roger Le Grand 3 Sylvie van Der Werf 5, 4 Jérémie Guedj 1 
Abstract : Non-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a mathematical model to characterize in detail the viral dynamics in 31 cynomolgus macaques for which nasopharyngeal and tracheal viral load were frequently assessed. We identified that infected cells had a large burst size (>10 4 virus) and a within-host reproductive basic number of approximately 6 and 4 in nasopharyngeal and tracheal compartment, respectively. After peak viral load, infected cells were rapidly lost with a half-life of 9 hours, with no significant association between cytokine elevation and clearance, leading to a median time to viral clearance of 10 days, consistent with observations in mild human infections. Given these parameter estimates, we predict that a prophylactic treatment blocking 90% of viral production or viral infection could prevent viral growth. In conclusion, our results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03207908
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Submitted on : Monday, April 26, 2021 - 11:07:34 AM
Last modification on : Wednesday, September 28, 2022 - 5:57:27 AM
Long-term archiving on: : Tuesday, July 27, 2021 - 6:38:21 PM

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journal.pcbi.1008785.pdf
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Antonio Gonçalves, Pauline Maisonnasse, Flora Donati, Mélanie Albert, Sylvie Behillil, et al.. SARS-CoV-2 viral dynamics in non-human primates. PLoS Computational Biology, 2021, 17 (3), pp.e1008785. ⟨10.1371/journal.pcbi.1008785⟩. ⟨pasteur-03207908⟩

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