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SARS-CoV-2 viral dynamics in non-human primates

Antonio Gonçalves 1, * Pauline Maisonnasse 2 Flora Donati 3, 4 Mélanie Albert 4 Sylvie Behillil 3, 4 Vanessa Contreras 2 Thibaut Naninck 2 Romain Marlin 2 Caroline Solas 5 Andres Pizzorno 6 Julien Lemaitre 2 Nidhal Kahlaoui 2 Olivier Terrier 6, 7 Raphael Ho Tsong Fang 2 Vincent Enouf 4, 3, 8 Nathalie Dereuddre-Bosquet 2 Angela Brisebarre 4, 3 Franck Touret 5 Catherine Chapon 2 Bruno Hoen 9 Bruno Lina 6, 10 Manuel Rosa Calatrava 6 Xavier de Lamballerie 5 France Mentré 1 Roger Le Grand 2 Sylvie van Der Werf 4, 3 Jérémie Guedj 1 
Abstract : Non-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a mathematical model to characterize in detail the viral dynamics in 31 cynomolgus macaques for which nasopharyngeal and tracheal viral load were frequently assessed. We identified that infected cells had a large burst size (>10 4 virus) and a within-host reproductive basic number of approximately 6 and 4 in nasopharyngeal and tracheal compartment, respectively. After peak viral load, infected cells were rapidly lost with a half-life of 9 hours, with no significant association between cytokine elevation and clearance, leading to a median time to viral clearance of 10 days, consistent with observations in mild human infections. Given these parameter estimates, we predict that a prophylactic treatment blocking 90% of viral production or viral infection could prevent viral growth. In conclusion, our results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments.
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Submitted on : Monday, April 26, 2021 - 11:07:34 AM
Last modification on : Thursday, April 14, 2022 - 5:26:01 PM
Long-term archiving on: : Tuesday, July 27, 2021 - 6:38:21 PM


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Antonio Gonçalves, Pauline Maisonnasse, Flora Donati, Mélanie Albert, Sylvie Behillil, et al.. SARS-CoV-2 viral dynamics in non-human primates. PLoS Computational Biology, Public Library of Science, 2021, 17 (3), pp.e1008785. ⟨10.1371/journal.pcbi.1008785⟩. ⟨pasteur-03207908⟩



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