Kinetics of nasopharyngeal shedding of novel H1N1 (swine-like) influenza A virus in an immunocompetent adult under oseltamivir therapy [case report]

C. Charlier (1) , V. Enouf (2) , F. Lanternier (1) , M. Grandadam (3) , K. Amazzough (1) , S. Blanche (4) , Marc Lecuit (1) , Olivier Lortholary (1) , Sylvie van Der Werf (2)

1 Service des Maladies infectieuses et tropicales [CHU Necker]
2 CNR - Centre National de Référence des virus influenzae (Grippe)
3 Interactions Moléculaires Flavivirus-Hôtes
4 CHU Necker - Enfants Malades [AP-HP] - Unité d'Immunologie et d'Hématologie Pédiatrique

We describe a patient with confirmed novel H1N1 (swine-like) influenza A virus who had daily nasal swabs tested during oseltamivir therapy. Nasal shedding remained positive for 2 days and became negative on day 3. This report presents the first available data on the kinetics of shedding of this novel virus under antiviral therapy.

Keywords: Kinetics; nasal shedding; oseltamivir; PCR; swinerelated influenza

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Human health and pathology; Life Sciences [q-bio]; Human health and pathology; Infectious diseases; Life Sciences [q-bio]; Human health and pathology; Emerging diseases; Life Sciences [q-bio]; Microbiology and Parasitology; Life Sciences [q-bio]; Microbiology and Parasitology; Virology; Life Sciences [q-bio]; Immunology

C. Charlier, V. Enouf, F. Lanternier, M. Grandadam, K. Amazzough, et al.. Kinetics of nasopharyngeal shedding of novel H1N1 (swine-like) influenza A virus in an immunocompetent adult under oseltamivir therapy [case report]. Clinical Microbiology and Infection, 2009, 15 (12), pp.1189-1190. ⟨10.1111/j.1469-0691.2009.03007.x⟩. ⟨pasteur-03203918⟩