“Chronic Disseminated Aspergillosis,” a Novel Fungal Immune Reconstitution Inflammatory Syndrome

Annabelle Pourbaix (1) , Romain Guery (1) , Julie Bruneau (2) , Estelle Blanc (3) , Gregory Jouvion (4) , Marthe Weinandt (5, 6) , Claire Rouzaud (1) , Jérémy Lourenço (1) , David Boutboul (7, 8) , Jean-Paul Mira (9) , Alexandre Rouquette (10) , Thierry Jo Molina (2) , Marc Lecuit (1, 11) , Olivier Lortholary (1, 12)

1 Service des Maladies infectieuses et tropicales [CHU Necker]
2 Département de Pathologie [CHU Necker]
3 Hôpital Marie-Lannelongue
4 CHU Trousseau [APHP]
5 Hôpital Cochin [AP-HP]
6 UPD5 - Université Paris Descartes - Paris 5
7 Service d'Immunopathologie [Hôpital Saint-Louis, Paris]
8 HIPI (UMR_S_976 / U976) - Immunologie humaine, physiopathologie & immunothérapie
9 Unité de Soins Intensifs [CHU Cochin]
10 Service de Pathologie [AP-HP Hôpital Cochin]
11 Biologie des Infections - Biology of Infection
12 Mycologie moléculaire - Molecular Mycology

We report a case of chronic hepatosplenic aspergillosis following immune reconstitution complicating colic aspergillosis in an AIDS patient with multicentric Castleman disease. Symptoms mimicked the clinical presentation of chronic disseminated candidiasis and responded to corticosteroid. This emerging entity enlarges the spectrum of fungal immune reconstitution inflammatory syndrome in the HIV setting.

Keywords: aspergillosis; hepatosplenic; immune reconstitution inflammatory syndrome

Domains: Life Sciences [q-bio]; Human health and pathology; Infectious diseases; Mycology; Immunology

Annabelle Pourbaix, Romain Guery, Julie Bruneau, Estelle Blanc, Gregory Jouvion, et al.. “Chronic Disseminated Aspergillosis,” a Novel Fungal Immune Reconstitution Inflammatory Syndrome. Open Forum Infectious Diseases, 2020, 7 (11), pp.ofaa175. ⟨10.1093/ofid/ofaa175⟩. ⟨pasteur-03203254⟩