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Journal articles
The Battle Within: Interactions of Bacteriophages and Bacteria in the Gastrointestinal Tract
Abstract : The intestinal microbiota is intimately linked to human health. Decoding the mechanisms underlying its stability in healthy subjects should uncover causes of microbiota-associated diseases and pave the way for treatment. Bacteria and bacteriophages (phages) are the most abundant biological entities in the gastrointestinal tract, where their coexistence is dynamic and affixed. Phages drive and maintain bacterial diversity by perpetuating the coevolutionary interactions with their microbial prey. This review brings together recent in silico, in vitro, and in vivo work dissecting the complexity of phage-bacteria interactions in the intestinal microbiota, including coevolution perspectives. We define the types of dynamics encountered in the gastrointestinal tract and the parameters that affect their outcome. The impact of intestinal physiology on phagebacterial coevolution is analyzed in the light of its potential contribution to the relationship between the microbiota and human health.
https://hal-pasteur.archives-ouvertes.fr/pasteur-03164325
Contributor : Ana Cova Rodrigues Connect in order to contact the contributor
Submitted on : Wednesday, March 17, 2021 - 1:37:43 PM
Last modification on : Monday, January 17, 2022 - 3:10:02 PM
Long-term archiving on: : Monday, June 21, 2021 - 8:59:30 AM
Contributor : Ana Cova Rodrigues Connect in order to contact the contributor
Submitted on : Wednesday, March 17, 2021 - 1:37:43 PM
Last modification on : Monday, January 17, 2022 - 3:10:02 PM
Long-term archiving on: : Monday, June 21, 2021 - 8:59:30 AM
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Distributed under a Creative Commons Attribution - NonCommercial 4.0 International License