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Fluid migration during bleb formation in cells in vivo

Abstract : Blebs are cellular protrusions observed in migrating cells and in cells undergoing spreading, cytokinesis, and apoptosis. Here we investigate the flow of cytoplasm during bleb formation and the concurrent changes in cell volume using zebrafish primordial germ cells (PGCs) as an in vivo model. We show that bleb inflation occurs concomitantly with cytoplasmic inflow into it and that during this process the total cell volume does not change. We thus show that bleb formation in primordial germ cells results primarily from redistribution of material within the cell rather than being driven by flow of water from an external source.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03152920
Contributor : Aleix Boquet-Pujadas <>
Submitted on : Thursday, February 25, 2021 - 9:54:16 PM
Last modification on : Tuesday, March 2, 2021 - 4:58:05 PM
Long-term archiving on: : Wednesday, May 26, 2021 - 7:27:48 PM

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Distributed under a Creative Commons Attribution 4.0 International License

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Mohammad Goudarzi, Aleix Boquet-Pujadas, Jean-Christophe Olivo-Marin, Erez Raz. Fluid migration during bleb formation in cells in vivo. PLoS ONE, Public Library of Science, 2019, 14 (2), pp.e0212699. ⟨10.1371/journal.pone.0212699⟩. ⟨pasteur-03152920⟩

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