Skip to Main content Skip to Navigation
Preprints, Working Papers, ...

High-risk exposure without personal protective equipment and infection with SARS-CoV-2 in healthcare workers: results of the CoV-CONTACT prospective cohort

Sarah Tubiana 1, 2, 3 Charles Burdet 1, 2, 4 Nadhira Houhou 5 Michael Thy 1 Pauline Manchon 1, 4 François Blanquart 2, 6 Charlotte Charpentier 2, 5 Jérémie Guedj 1, 2 Loubna Alavoine 1 Sylvie Behillil 7, 8 Anne Leclercq 9 Jean-Christophe Lucet 2, 10 yazdan yazdanpanah 2, 11 Mikaël Attia 12 Caroline Demeret 7 Thierry Rose 13 Julia Anna Bielicki 14, 15 Patricia Bruijning-Verhagen 16 Herman Goossens 17 Diane Descamps 2, 5 Sylvie van Der Werf 7, 8 Bruno Lina 18, 19 Xavier Duval 1, 2, * 
Abstract : Objective: We aimed to estimate the risk of infection in Healthcare workers (HCWs) following a high-risk exposure without personal protective equipment (PPE). Methods: We conducted a prospective cohort in HCW s who had a high-risk exposure to SARS-CoV-2-infected subject without PPE. Daily symptoms were self-reported for 30 days, nasopharyngeal swabs for SARS-CoV-2 RT-PCR were performed at inclusion and at days 3, 5, 7 and 12, SARS-CoV-2 serology was assessed at inclusion and at day 30. Confirmed infection was defined by positive RT-PCR or seroconversion, and possible infection by one general and one specific symptom for two consecutive days. Results: Between February 5th and May 30th, 2020, 154 HCWs were enrolled within 14 days following one high-risk exposure to either a hospital patient (70/154; 46.1%) and/or a colleague (95/154; 62.5%). At day 30, 2 5.0% had a confirmed infection (37/148; 95% CI, 18.4 %; 32.9%), and 43.9% (65/148; 95%CI, 35.9%; 52.3 %) had a confirmed or possible infection. Factors independently associated with confirmed or possible SARS-CoV-2 infection were being a pharmacist or administrative assistant rather than being from medical staff (adjusted OR (aOR)=3.8, CI95%=1 .3; 11.2, p=0.01) , and exposure to a SARS-CoV-2-inf ected patient rather than exposure to a SARS-CoV-2-infected colleague (a OR=2 .6, CI95%=1.2; 5.9, p=0.02). Among the 26 HCWs with a SARS-CoV-2-positive nasopharyngeal swab, 7 (26.9 %) had no symptom at the time of the RT-PCR positivity. Conclusions: The proportion of HCWs with confirmed or possible SARS-CoV-2 infection was high. There were less occurrences of high-risk exposure with patients than with colleagues, but those were associated with an increased risk of infection.
Document type :
Preprints, Working Papers, ...
Complete list of metadata
Contributor : caroline demeret Connect in order to contact the contributor
Submitted on : Wednesday, May 5, 2021 - 11:20:40 AM
Last modification on : Tuesday, April 19, 2022 - 9:56:59 AM
Long-term archiving on: : Friday, August 6, 2021 - 6:26:21 PM


Files produced by the author(s)





Sarah Tubiana, Charles Burdet, Nadhira Houhou, Michael Thy, Pauline Manchon, et al.. High-risk exposure without personal protective equipment and infection with SARS-CoV-2 in healthcare workers: results of the CoV-CONTACT prospective cohort. 2021. ⟨pasteur-03147092⟩



Record views


Files downloads