Molecular Basis of Phosphatidyl-myo-inositol Mannoside Biosynthesis and Regulation in Mycobacteria - Institut Pasteur Access content directly
Journal Articles Journal of Biological Chemistry Year : 2010

Molecular Basis of Phosphatidyl-myo-inositol Mannoside Biosynthesis and Regulation in Mycobacteria

Abstract

Phosphatidyl-myo-inositol mannosides (PIMs) are unique glycolipids found in abundant quantities in the inner and outer membranes of the cell envelope of all Mycobacterium species. They are based on a phosphatidyl-myo-inositol lipid anchor carrying one to six mannose residues and up to four acyl chains. PIMs are considered not only essential structural components of the cell envelope but also the structural basis of the lipoglycans (lipomannan and lipoarabinomannan), all important molecules implicated in host-pathogen interactions in the course of tuberculosis and leprosy. Although the chemical structure of PIMs is now well established, knowledge of the enzymes and sequential events leading to their biosynthesis and regulation is still incomplete. Recent advances in the identification of key proteins involved in PIM biogenesis and the determination of the three-dimensional structures of the essential phosphatidyl-myo-inositol mannosyltransferase PimA and the lipoprotein LpqW have led to important insights into the molecular basis of this pathway.
Fichier principal
Vignette du fichier
1-s2.0-S0021925820470681-main.pdf (1.29 Mo) Télécharger le fichier

Dates and versions

pasteur-03137935 , version 1 (10-02-2021)

Licence

Attribution - CC BY 4.0

Identifiers

Cite

Marcelo E. Guerin, Jana Korduláková, Pedro M. Alzari, Patrick J. Brennan, Mary Jackson. Molecular Basis of Phosphatidyl-myo-inositol Mannoside Biosynthesis and Regulation in Mycobacteria. Journal of Biological Chemistry, 2010, 285 (44), pp.33577-33583. ⟨10.1074/jbc.R110.168328⟩. ⟨pasteur-03137935⟩

Collections

PASTEUR CNRS
20 View
31 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More