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Crystallization and Preliminary Crystallographic Analysis of a Tetrameric Isolectin from Vicia villosa, Specific for the Tn Antigen

Jean-Luc Eiselé 1 Diana Tello 2 Eduardo Osinaga 3 Alberto Roseto 3 Pedro Alzari 2
3 Division d'immunocytologie appliquée [Compiègne]
UTC - Université de Technologie de Compiègne, CNRS - Centre National de la Recherche Scientifique : URA 1442
Abstract : Isolectin B4 isolated from Vicia villosa seeds is specific for the Tn antigen, a carcinoma-associated molecular marker. Crystals of the isolectin grown in the presence of carbohydrate are tetragonal, space group P 41 (or P43), with a = 91·3 Å, c = 151·7 Å and one tetramer in the asymmetric unit. The crystals diffract X-rays to 2·8 Å resolution and are suitable for high-resolution structural analysis.
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Submitted on : Tuesday, February 9, 2021 - 5:31:00 PM
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Jean-Luc Eiselé, Diana Tello, Eduardo Osinaga, Alberto Roseto, Pedro Alzari. Crystallization and Preliminary Crystallographic Analysis of a Tetrameric Isolectin from Vicia villosa, Specific for the Tn Antigen. Journal of Molecular Biology, Elsevier, 1993, 230 (2), pp.670-672. ⟨10.1006/jmbi.1993.1180⟩. ⟨pasteur-03136511⟩

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