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Vaccine-Derived Polioviruses, Central African Republic, 2019

Abstract : Since May 2019, the Central African Republic has experienced a poliomyelitis outbreak caused by type 2 vaccine-derived polioviruses (VDPV-2s). The outbreak affected Bangui, the capital city, and 10 districts across the country. The outbreak resulted from several independent emergence events of VDPV-2s featuring recombinant genomes with complex mosaic genomes. The low number of mutations (<20) in the viral capsid protein 1-encoding region compared with the vaccine strain suggests that VDPV-2 had been circulating for a relatively short time (probably <3 years) before being isolated. Environmental surveillance, which relies on a limited number of sampling sites in the Central African Republic and does not cover the whole country, failed to detect the circulation of VDPV-2s before some had induced poliomyelitis in children.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03122581
Contributor : Maël Bessaud <>
Submitted on : Wednesday, January 27, 2021 - 10:26:16 AM
Last modification on : Thursday, January 28, 2021 - 3:19:47 AM
Long-term archiving on: : Wednesday, April 28, 2021 - 6:30:57 PM

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Marie-Line Joffret, Joël Wilfried Doté, Nicksy Gumede, Marco Vignuzzi, Maël Bessaud, et al.. Vaccine-Derived Polioviruses, Central African Republic, 2019. Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2021, 27 (2), pp.620-623. ⟨10.3201/eid2702.203173⟩. ⟨pasteur-03122581⟩

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