Skip to Main content Skip to Navigation
Journal articles

Host Genetic Variation Does Not Determine Spatio-Temporal Patterns of European Bat 1 Lyssavirus

Abstract : The majority of bat rabies cases in Europe are attributed to European bat 1 lyssavirus (EBLV-1), circulating mainly in serotine bats (Eptesicus serotinus). Two subtypes have been defined (EBLV-1a and EBLV-1b), each associated with a different geographical distribution. In this study, we undertake a comprehensive sequence analysis based on 80 newly obtained EBLV-1 nearly complete genome sequences from nine European countries over a 45-year period to infer selection pressures, rates of nucleotide substitution, and evolutionary time scale of these two subtypes in Europe. Our results suggest that the current lineage of EBLV-1 arose in Europe $600 years ago and the virus has evolved at an estimated average substitution rate of $4.19Â10 À5 subs/site/ year, which is among the lowest recorded for RNA viruses. In parallel, we investigate the genetic structure of French serotine bats at both the nuclear and mitochondrial level and find that they constitute a single genetic cluster. Furthermore, Mantel tests based on interindividual distances reveal the absence of correlation between genetic distances estimated between viruses and between host individuals. Taken together, this indicates that the genetic diversity observed in our E. serotinus samples does not account for EBLV-1a and-1b segregation and dispersal in Europe.
Document type :
Journal articles
Complete list of metadata

https://hal-pasteur.archives-ouvertes.fr/pasteur-03112525
Contributor : Laurent Dacheux <>
Submitted on : Saturday, January 16, 2021 - 7:58:22 PM
Last modification on : Tuesday, July 6, 2021 - 2:50:07 PM
Long-term archiving on: : Saturday, April 17, 2021 - 6:31:38 PM

File

evx236.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution - NonCommercial 4.0 International License

Identifiers

Collections

Citation

Cécile Troupin, Evelyne Picard-Meyer, Simon Dellicour, Isabelle Casademont, Lauriane Kergoat, et al.. Host Genetic Variation Does Not Determine Spatio-Temporal Patterns of European Bat 1 Lyssavirus. Genome Biology and Evolution, Society for Molecular Biology and Evolution, 2017, 9 (11), pp.3202-3213. ⟨10.1093/gbe/evx236⟩. ⟨pasteur-03112525⟩

Share

Metrics

Record views

62

Files downloads

140