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GATA-3 Promotes Maturation, IFN-γ Production, and Liver-Specific Homing of NK Cells

Abstract : The GATA-3 transcription factor has a determinant role in T cell specification and is an essential mediator of T helper 2-type polarized immune responses. While both committed NK precursors and mature NK cells express GATA-3, a role of this transcription factor in murine NK cell differentiation is not known. We found that NK cells, in contrast to T cells, can be generated in the absence of GATA-3. However, while GATA-3 antagonizes IFN-gamma production in differentiating T cells, GATA-3-deficient NK cells paradoxically produced less IFN-gamma compared to control NK cells and failed to provide early protection in vivo against infection with Listeria monocytogenes. Surprisingly, GATA-3 was essential for NK cell homing to the liver. Our results suggest that GATA-3 promotes NK cell maturation and acts in this lineage to specify distinct effector phenotypes.
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Contributor : Christian Vosshenrich Connect in order to contact the contributor
Submitted on : Wednesday, January 13, 2021 - 10:46:12 PM
Last modification on : Tuesday, October 19, 2021 - 10:27:01 PM

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Sandrine Samson, Odile Richard, Manuela Tavian, Thomas Ranson, Christian A. J. Vosshenrich, et al.. GATA-3 Promotes Maturation, IFN-γ Production, and Liver-Specific Homing of NK Cells. Immunity, Elsevier, 2003, 19 (5), pp.701-711. ⟨10.1016/s1074-7613(03)00294-2⟩. ⟨pasteur-03109723⟩



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