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Thymic stromal-derived lymphopoietin distinguishes fetal from adult B cell development

Abstract : Deletions of interleukin 7 (IL-7) or its receptor components permit fetal but not adult B cell development in mice. Mice deficient in IL-7 receptor alpha (IL-7R alpha) had 1% the number of B cells of controls and 10% that of mice deficient in the common gamma chain. As IL-7R alpha is also a receptor for thymic stromal-derived lymphopoietin (TSLP), we assayed the ability of TSLP to support proliferation of fetal or adult precursor B cells. Only fetal-derived pro-B cells were able to respond to TSLP, although pre-B cells from both origins were TSLP-responsive. Fetal but not adult precursors generated a measurable B cell compartment in the absence of IL-7. The residual B cells found in IL-7R alpha-deficient mice required fetal liver kinase 2 (Flk-2) for their development. Thus, IL-7R alpha- and Flk-2-mediated signals account for the generation of almost all mouse B lymphocytes.
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Contributor : Christian Vosshenrich Connect in order to contact the contributor
Submitted on : Wednesday, January 13, 2021 - 10:44:31 PM
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Christian A. J. Vosshenrich, Ana Cumano, Werner Müller, James P Di Santo, Paulo Vieira. Thymic stromal-derived lymphopoietin distinguishes fetal from adult B cell development. Nature Immunology, Nature Publishing Group, 2003, 4 (8), pp.773-779. ⟨10.1038/ni956⟩. ⟨pasteur-03109721⟩



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