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A destabilised metabolic niche provokes loss of a subpopulation of aged muscle stem cells

Abstract : Ageing is a multi-factorial condition that results in a gradual decline in tissue and organ function. Systemic, local and intrinsic factors play major roles in this process that also results in a decline in stem cell number and function. In this issue of The EMBO Journal, Li et al (2019) show that a subpopulation of mouse muscle stem cells is depleted in aged mice through loss of niche-derived granulocyte colony-stimulating factor (G-CSF).
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Contributor : Brendan Evano <>
Submitted on : Monday, January 11, 2021 - 10:48:56 AM
Last modification on : Monday, January 18, 2021 - 4:08:02 PM

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Brendan Evano, Shahragim Tajbakhsh. A destabilised metabolic niche provokes loss of a subpopulation of aged muscle stem cells. EMBO Journal, EMBO Press, 2019, 38 (24), pp.e103924. ⟨10.15252/embj.2019103924⟩. ⟨pasteur-03105578⟩

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