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Journal articles
Mass‐spectrometry analysis of the human pineal proteome during night and day and in autism
Abstract : The human pineal gland regulates day‐night dynamics of multiple physiological processes, especially through the secretion of melatonin. Using mass spectrometry‐based proteomics and dedicated analysis tools, we identify proteins in the human pineal gland and analyze systematically their variation throughout the day, and, compare these changes in the pineal proteome between control specimens and donors diagnosed with autism. Results reveal diverse regulated clusters of proteins with, among others, catabolic carbohydrate process and cytoplasmic membrane‐bounded vesicle‐related proteins differing between day and night and/or control versus autism pineal glands. These data show novel and unexpected processes happening in the human pineal gland during the day/night rhythm as well as specific differences between autism donor pineal glands and those from controls.
https://hal-pasteur.archives-ouvertes.fr/pasteur-03096880
Contributor : Virginie Portelette <>
Submitted on : Tuesday, March 30, 2021 - 10:43:49 AM
Last modification on : Thursday, August 26, 2021 - 11:34:07 AM
Contributor : Virginie Portelette <>
Submitted on : Tuesday, March 30, 2021 - 10:43:49 AM
Last modification on : Thursday, August 26, 2021 - 11:34:07 AM
File
jpi.12713.pdf
Publication funded by an institution
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Distributed under a Creative Commons Attribution 4.0 International License