CRSN/Faculté de médecine Université de Montréal (CRSN/Faculté de médecine Université de Montréal Pav. Paul-G.-Desmarais, 4139 or 2140 2960, chemin de la Tour Montréal (Québec) H3T 1J4 - Canada)
Abstract : The human pineal gland regulates day‐night dynamics of multiple physiological processes, especially through the secretion of melatonin. Using mass spectrometry‐based proteomics and dedicated analysis tools, we identify proteins in the human pineal gland and analyze systematically their variation throughout the day, and, compare these changes in the pineal proteome between control specimens and donors diagnosed with autism. Results reveal diverse regulated clusters of proteins with, among others, catabolic carbohydrate process and cytoplasmic membrane‐bounded vesicle‐related proteins differing between day and night and/or control versus autism pineal glands. These data show novel and unexpected processes happening in the human pineal gland during the day/night rhythm as well as specific differences between autism donor pineal glands and those from controls.
https://hal-pasteur.archives-ouvertes.fr/pasteur-03096880 Contributor : Virginie PORTELETTEConnect in order to contact the contributor Submitted on : Tuesday, March 30, 2021 - 10:43:49 AM Last modification on : Thursday, April 14, 2022 - 4:06:01 PM
Guillaume Dumas, Hany Goubran‐botros, Mariette I Matondo, Cécile Pagan, Cyril Boulègue, et al.. Mass‐spectrometry analysis of the human pineal proteome during night and day and in autism. Journal of Pineal Research, Wiley, 2020, 70, ⟨10.1111/jpi.12713⟩. ⟨pasteur-03096880⟩