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Retrospective screening for heterogeneous vancomycin resistance in diverse Staphylococcus aureus clones disseminated in French hospitals

Abstract : Twenty-five different Staphylococcus aureus strains that are widespread in France were screened by various methods for heterogeneous and low-level resistance to vancomycin. Population analysis on brain-heart infusion agar containing 4 mg/L of the drug detected resistant cells at frequencies of 10-7 to 10-6 in five multiply resistant strains. There was no antagonism between vancomycin and beta-lactam antibiotics. One of the five strains, isolated in 1993, was considered a putative progenitor of a French nosocomial S. aureus strain isolated in 1998 and for which the vancomycin MIC was 8 mg/L.
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Contributor : Olivier Chesneau <>
Submitted on : Friday, December 18, 2020 - 3:54:25 PM
Last modification on : Wednesday, January 27, 2021 - 9:37:44 PM

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Olivier Chesneau, A. Morvan, N. Solh. Retrospective screening for heterogeneous vancomycin resistance in diverse Staphylococcus aureus clones disseminated in French hospitals. Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2000, 45 (6), pp.887-890. ⟨10.1093/jac/45.6.887⟩. ⟨pasteur-03082468⟩

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