Resistance Genes Underlying the LS A Phenotype of Staphylococcal Isolates from France

Sophie Tesse (1) , François Trueba (1) , Nicolas Berthet (2) , Chloe Hot (3) , Olivier Chesneau (3)

1 Hôpital d'Instruction des Armées du Val de Grâce
2 EPVO (UMR_3569 / U-Pasteur_3) - Epidémiologie et Physiopathologie des Virus Oncogènes
3 Membranes bactériennes

There exist numerous genes disseminated by mobile elements that can confer cross-resistance to lincosamides and streptogramin A compounds in staphylococci. This study investigated the nature and means of dissemination of genes responsible for LSA resistance among 24 French clinical isolates screened for reduced susceptibility to lincomycin. The vga(A)v gene was found to be the most prevalent determinant of LSA resistance, while Tn5406 appeared to be its exclusive gene support.

Domains: Bacteriology

Sophie Tesse, François Trueba, Nicolas Berthet, Chloe Hot, Olivier Chesneau. Resistance Genes Underlying the LS A Phenotype of Staphylococcal Isolates from France. Antimicrobial Agents and Chemotherapy, 2013, 57 (9), pp.4543-4546. ⟨10.1128/AAC.00259-13⟩. ⟨pasteur-03082451⟩