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Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry

Alexander Leitner 1 Alexandre Bonvin 2 Christoph Borchers 3, 4, 5 Robert Chalkley 6 Julia Chamot-Rooke 7 Colin Combe 8 Jürgen Cox 9 Meng-Qiu Dong 10 Lutz Fischer 11 Michael Götze 1 Fabio Gozzo 12 Albert Heck 2 Michael Hoopmann 13 Lan Huang 14 Yasushi Ishihama 15 Andrew Jones 16 Nir Kalisman 17 Oliver Kohlbacher 18, 19 Karl Mechtler 20 Robert Moritz 13 Eugen Netz 18, 19 Petr Novak 21 Evgeniy Petrotchenko 4, 5 Andrej Sali 6 Richard Scheltema 2 Carla Schmidt 22 David Schriemer 23 Andrea Sinz 22 Frank Sobott 24, 25 Florian Stengel 26 Konstantinos Thalassinos 27, 28 Henning Urlaub 29 Rosa Viner 30 Juan Vizcaíno 31 Marc Wilkins 32 Juri Rappsilber 8, *
* Corresponding author
Abstract : Cross-linking mass spectrometry (MS) has substantially matured as a method over the past 2 decades through parallel development in multiple labs, demonstrating its applicability to protein structure determination, conformation analysis, and mapping protein interactions in complex mixtures. Cross-linking MS has become a much-appreciated and routinely applied tool, especially in structural biology. Therefore, it is timely that the community commits to the development of methodological and reporting standards. This white paper builds on an open process comprising a number of events at community conferences since 2015 and identifies aspects of Cross-linking MS for which guidelines should be developed as part of a Cross-linking MS standards initiative.
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Submitted on : Tuesday, December 15, 2020 - 7:30:13 PM
Last modification on : Wednesday, January 19, 2022 - 1:44:01 PM

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Alexander Leitner, Alexandre Bonvin, Christoph Borchers, Robert Chalkley, Julia Chamot-Rooke, et al.. Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry. Structure, Elsevier (Cell Press), 2020, 28 (11), pp.1259-1268. ⟨10.1016/j.str.2020.09.011⟩. ⟨pasteur-03070494⟩



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