Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry
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Alexandre Bonvin
- Function : Author
- PersonId : 803831
- ORCID : 0000-0001-7369-1322
- IdRef : 190948361
Julia Chamot-Rooke
- Function : Author
- PersonId : 742132
- IdHAL : jchamot
- ORCID : 0000-0002-9427-543X
- IdRef : 119949687
Karl Mechtler
- Function : Author
- PersonId : 797565
- ORCID : 0000-0002-3392-9946
Juri Rappsilber
Connectez-vous pour contacter l'auteur
- Function : Correspondent author
- PersonId : 1087025
Connectez-vous pour contacter l'auteur
Abstract
Cross-linking mass spectrometry (MS) has substantially matured as a method over the past 2 decades through parallel development in multiple labs, demonstrating its applicability to protein structure determination, conformation analysis, and mapping protein interactions in complex mixtures. Cross-linking MS has become a much-appreciated and routinely applied tool, especially in structural biology. Therefore, it is timely that the community commits to the development of methodological and reporting standards. This white paper builds on an open process comprising a number of events at community conferences since 2015 and identifies aspects of Cross-linking MS for which guidelines should be developed as part of a Cross-linking MS standards initiative.