Journal articles

Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry

Alexander Leitner ¹ Alexandre Bonvin ² Christoph Borchers ^{3, 4, 5} Robert Chalkley ⁶ Julia Chamot-Rooke ⁷ Colin Combe ⁸ Jürgen Cox ⁹ Meng-Qiu Dong ¹⁰ Lutz Fischer ¹¹ Michael Götze ¹ Fabio Gozzo ¹² Albert Heck ² Michael Hoopmann ¹³ Lan Huang ¹⁴ yasushi Ishihama ¹⁵ Andrew Jones ¹⁶ Nir Kalisman ¹⁷ Oliver Kohlbacher ^{18, 19} Karl Mechtler ²⁰ Robert Moritz ¹³ Eugen Netz ^{18, 19} Petr Novak ²¹ Evgeniy Petrotchenko ^{4, 5} Andrej Sali ⁶ Richard Scheltema ² Carla Schmidt ²² David Schriemer ²³ Andrea Sinz ²² Frank Sobott ^{24, 25} Florian Stengel ²⁶ Konstantinos Thalassinos ^{27, 28} Henning Urlaub ²⁹ Rosa Viner ³⁰ Juan Vizcaíno ³¹ Marc Wilkins ³² Juri Rappsilber ^{8, *}

* Corresponding author

1 ETH Zürich - Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich]

2 Utrecht University [Utrecht]

3 UVIC - University of Victoria [Canada]

4 Lady Davis Institute for Medical Research [Montréal]

5 Skoltech - Skolkovo Institute of Science and Technology [Moscow]

6 UCSF - University of California [San Francisco]

7 UTechS MSBio - Spectrométrie de Masse pour la Biologie – Mass Spectrometry for Biology

8 University of Edinburgh

9 MPIB - Max Planck Institute of Biochemistry

10 Number 7 Science Park Road - National Institute of Biological Sciences [Beijing, China]

11 TU - Technische Universität Berlin

12 UNICAMP - University of Campinas [Campinas]

13 ISB - Institute for Systems Biology [Seattle]

14 UCI - University of California [Irvine]

15 Kyoto University [Kyoto]

16 University of Liverpool

17 HUJ - The Hebrew University of Jerusalem

18 University of Tübingen

19 Max Planck Institute for Developmental Biology

20 IMP - Research Institute of Molecular Pathology

21 CU - Charles University [Prague]

22 Martin-Luther-University Halle-Wittenberg

23 University of Calgary

24 University of Leeds

25 UA - University of Antwerp

26 University of Konstanz

27 Birkbeck College [University of London]

28 UCL - University College of London [London]

29 Max-Planck-Institut für Biophysikalische Chemie - Max Planck Institute for Biophysical Chemistry [Göttingen]

30 Thermo Fisher Scientific (Bremen) GmbH

31 EMBL-EBI - European Bioinformatics Institute [Hinxton]

32 UNSW - University of New South Wales [Sydney]

Abstract : Cross-linking mass spectrometry (MS) has substantially matured as a method over the past 2 decades through parallel development in multiple labs, demonstrating its applicability to protein structure determination, conformation analysis, and mapping protein interactions in complex mixtures. Cross-linking MS has become a much-appreciated and routinely applied tool, especially in structural biology. Therefore, it is timely that the community commits to the development of methodological and reporting standards. This white paper builds on an open process comprising a number of events at community conferences since 2015 and identifies aspects of Cross-linking MS for which guidelines should be developed as part of a Cross-linking MS standards initiative.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Biochemistry, Molecular Biology

Complete list of metadata

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Submitted on : Tuesday, December 15, 2020 - 7:30:13 PM
Last modification on : Thursday, April 14, 2022 - 3:18:01 PM