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Origin, evolution and global spread of SARS-CoV-2

Abstract : SARS-CoV-2 is the virus responsible for the global COVID19 pandemic. We review what is known about the origin of this virus, detected in China at the end of December 2019. The genome of this virus mainly evolves under the effect of point mutations. These are generally neutral and have no impact on virulence and severity, but some appear to influence infectivity, notably the D614G mutation of the Spike protein. To date (30/09/2020) no recombination of the virus has been documented in the human host, and very few insertions and deletions. The worldwide spread of the virus was the subject of controversies that we summarize, before proposing a new approach free from the limitations of previous methods. The results show a complex scenario with, for example, numerous introductions to the USA and returns of the virus from the USA to certain countries including France.
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Contributor : Lemoine Frédéric Connect in order to contact the contributor
Submitted on : Thursday, December 3, 2020 - 4:07:26 PM
Last modification on : Monday, November 21, 2022 - 10:42:07 AM
Long-term archiving on: : Thursday, March 4, 2021 - 7:32:43 PM


Distributed under a Creative Commons Attribution 4.0 International License



Anna Zhukova, Luc Blassel, Frédéric Lemoine, Marie Morel, Jakub Voznica, et al.. Origin, evolution and global spread of SARS-CoV-2. Comptes Rendus Biologies, 2021, pp.1-19. ⟨10.5802/crbiol.29⟩. ⟨pasteur-03038752⟩



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