Skip to Main content Skip to Navigation
New interface
Journal articles

An original infection model identifies host lipoprotein import as a route for blood-brain barrier crossing

Abstract : Pathogens able to cross the blood-brain barrier (BBB) induce long-term neurological sequelae and death. Understanding how neurotropic pathogens bypass this strong physiological barrier is a prerequisite to devise therapeutic strategies. Here we propose an innovative model of infection in the developing Drosophila brain, combining whole brain explants with in vivo systemic infection. We find that several mammalian pathogens are able to cross the Drosophila BBB, including Group B Streptococcus (GBS). Amongst GBS surface components, lipoproteins, and in particular the B leucine-rich Blr, are important for BBB crossing and virulence in Drosophila. Further, we identify (V)LDL receptor LpR2, expressed in the BBB, as a host receptor for Blr, allowing GBS translocation through endocytosis. Finally, we show that Blr is required for BBB crossing and pathogenicity in a murine model of infection. Our results demonstrate the potential of Drosophila for studying BBB crossing by pathogens and identify a new mechanism by which pathogens exploit the machinery of host barriers to generate brain infection.
Document type :
Journal articles
Complete list of metadata
Contributor : Pascale SITBON Connect in order to contact the contributor
Submitted on : Thursday, December 3, 2020 - 11:16:12 AM
Last modification on : Thursday, April 7, 2022 - 10:10:54 AM
Long-term archiving on: : Thursday, March 4, 2021 - 6:50:18 PM


Publication funded by an institution


Distributed under a Creative Commons Attribution 4.0 International License




Billel Benmimoun, Florentia Papastefanaki, Bruno Périchon, Katerina Segklia, Nicolas Roby, et al.. An original infection model identifies host lipoprotein import as a route for blood-brain barrier crossing. Nature Communications, 2020, 11 (1), pp.6106. ⟨10.1038/s41467-020-19826-2⟩. ⟨pasteur-03037742⟩



Record views


Files downloads