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Journal articles
Bisubstrate-Type Chemical Probes Identify GRP94 as a Potential Target of Cytosine-Containing Adenosine Analogs
Abstract : We synthesized affinity-based chemical probes of cytosine-adenosine bisubstrate analogs and identified several potential targets by proteomic analysis. The validation of the proteomic analysis identified the chemical probe as a specific inhibitor of glucose-regulated protein 94 (GRP94), a potential drug target for several types of cancers. Therefore, as a result of the use of bisubstrate-type chemical probes and a chemical-biology methodology, this work opens the way to the development of a new family of GRP94 inhibitors that could potentially be of therapeutic interest.
https://hal-pasteur.archives-ouvertes.fr/pasteur-03026521
Contributor : Martine Belin <>
Submitted on : Friday, January 1, 2021 - 4:44:55 PM
Last modification on : Wednesday, September 15, 2021 - 11:40:07 AM
Long-term archiving on: : Friday, April 2, 2021 - 6:34:38 PM
Contributor : Martine Belin <>
Submitted on : Friday, January 1, 2021 - 4:44:55 PM
Last modification on : Wednesday, September 15, 2021 - 11:40:07 AM
Long-term archiving on: : Friday, April 2, 2021 - 6:34:38 PM
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