, Biologie cellulaire, Annales de l'Institut Pasteur / Virologie, vol.132, issue.1, pp.119-120, 1981.
Immunology of Chlamydia infection: implications for a Chlamydia trachomatis vaccine, Nature Reviews Immunology, vol.5, issue.2, pp.149-161, 2005. ,
Make It a Sweet Home: Responses of Chlamydia trachomatis to the Challenges of an Intravacuolar Lifestyle, Bacteria and Intracellularity, vol.7, pp.167-177, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02379168
Targeting eukaryotic Rab proteins: a smart strategy for chlamydial survival and replication, Cellular Microbiology, vol.16, issue.9, pp.1329-1338, 2014. ,
Chlamydia cell biology and pathogenesis, Nature Reviews Microbiology, vol.14, issue.6, pp.385-400, 2016. ,
The Loss of Expression of a Single Type 3 Effector (CT622) Strongly Reduces Chlamydia trachomatis Infectivity and Growth, Frontiers in Cellular and Infection Microbiology, vol.8, p.546, 2018. ,
The Loss of Expression of a Single Type 3 Effector (CT622) Strongly Reduces Chlamydia trachomatis Infectivity and Growth, Frontiers in Cellular and Infection Microbiology, vol.8, issue.145, p.145, 2018. ,
Historical landmarks of autophagy research, Cell Research, vol.24, issue.1, pp.9-23, 2013. ,
The WD40 domain of ATG16L1 is required for its non-550 canonical role in lipidation of LC3 at single membranes, The EMBO Journal, vol.551, issue.4, pp.97840-97817, 2018. ,
Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins, Journal of Cell Biology, vol.217, issue.3, pp.813-822, 2017. ,
Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes, Nature Cell Biology, vol.21, issue.3, pp.372-383, 2019. ,
The Protein ATG16L1 Suppresses Inflammatory Cytokines 558 Induced by the Intracellular Sensors Nod1 and Nod2 in an, Autophagy-Independent, vol.559, 2013. ,
The Protein ATG16L1 Suppresses Inflammatory Cytokines Induced by the Intracellular Sensors Nod1 and Nod2 in an Autophagy-Independent Manner, Immunity, vol.39, issue.5, pp.858-873, 2013. ,
Structure of the WD40-domain of human ATG16L1, Protein Science, vol.26, issue.9, pp.1828-1837, 2017. ,
TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3, The EMBO Journal, vol.32, issue.4, pp.566-582, 2013. ,
Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis, Nature Communications, vol.10, issue.1, p.1834, 2019. ,
Autophagy-independent function of MAP-LC3 during 568 intracellular propagation of Chlamydia trachomatis, Autophagy, vol.7, issue.8, p.15, 2011. ,
Quantitative Monitoring of the Chlamydia trachomatis Developmental Cycle Using GFP-Expressing Bacteria, Microscopy and Flow Cytometry, PLoS ONE, vol.9, issue.6, p.e99197, 2014. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01448137
, PLoS One, vol.9, issue.6, pp.99197-572
The Novel Membrane Protein TMEM59 Modulates Complex Glycosylation, Cell Surface Expression, and Secretion of the Amyloid Precursor Protein, Journal of Biological Chemistry, vol.285, issue.27, pp.20664-20674, 2010. ,
The Novel Membrane Protein TMEM59 Modulates Complex Glycosylation, Cell Surface Expression, and Secretion of the Amyloid Precursor Protein, Journal of Biological Chemistry, vol.285, issue.27, pp.20664-20674, 2010. ,
Rab GTPases Are Recruited to Chlamydial Inclusions in Both a Species-Dependent and Species-Independent Manner, Infection and Immunity, vol.71, issue.10, pp.5855-5870, 2003. ,
The late endocytic Rab39a GTPase regulates the 579 interaction between multivesicular bodies and chlamydial inclusions, J. Cell Sci, vol.580, issue.16, pp.3068-3081, 2015. ,
Chlamydia trachomatis Intercepts Golgi-Derived 585 Sphingolipids through a Rab14-Mediated Transport Required for Bacterial 586 Development and Replication, Capmany A & Damiani MaT, vol.583, issue.10, pp.14084-587, 2009. ,
Associations of elements of the Golgi apparatus with microtubules., Journal of Cell Biology, vol.99, issue.3, pp.1092-1100, 1984. ,
WD40 Repeat Proteins: Signalling Scaffold with Diverse Functions, The Protein Journal, vol.37, issue.5, pp.391-406, 2018. ,
Transport and sorting in the Golgi complex: multiple mechanisms sort diverse cargo, Current Opinion in Cell Biology, vol.50, pp.94-101, 2018. ,
A genome-wide association scan of nonsynonymous SNPs 594 identifies a susceptibility variant for Crohn disease in ATG16L1, Nat. Genet, vol.39, p.25, 2006. ,
A Crohn?s disease variant in Atg16l1 enhances its degradation by caspase 3, Nature, vol.506, issue.7489, pp.456-462, 2014. ,
Autophagy and Inflammation, Annual Review of Immunology, vol.36, issue.1, pp.73-101, 2018. ,
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells, Nature, vol.456, issue.7219, pp.259-263, 2008. ,
The Inflammatory Bowel Disease-Associated Autophagy Gene 602, 2017. ,
The Inflammatory Bowel Disease?Associated Autophagy Gene Atg16L1T300A Acts as a Dominant Negative Variant in Mice, The Journal of Immunology, vol.198, issue.6, pp.2457-2467, 2017. ,
Genome engineering using the CRISPR-Cas9 system, Nature Protocols, vol.8, issue.11, pp.2281-2308, 2013. ,
Sequestration of host metabolism by an intracellular pathogen, eLife, vol.5, p.31, 2016. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01397781
Analyzing real-time PCR data by the comparative CT method, Nature Protocols, vol.3, issue.6, pp.1101-1108, 2008. ,
Trans Atlantic Infrasound Payload (TAIP) Operation Plan., TaiP D480A compared to Flag-TaiP, p.4, 2018. ,
, Figure 4. The predicted EMC1 transmembrane domain residue D961 plays a critical role during SV40 infection., E) Quantification of the average inclusion size in cells expressing Flag-CymR, Flag-TaiP 704 and Flag-TaiP D480A . Cells were transfected for 24 hrs before they were infected for 20 hrs with 705
, Figure 3?figure supplement 2. Characterization of C. trachomatis Cdu1-FLAG.
, Figure 7?video 1. Loss of GEF-H1, PLC?, or PKD impairs the localized delivery of Rab6-positive vesicles to FAs.
, Figure 3. VP3 mediates MAVS interaction and degradation using an N-terminal domain.
, Figure 14?figure supplement 1. Protein immunoblot showing the expression of different constructs in HeLa cells.
, Figure 3?figure supplement 3. Cdu1 expression in C.
Figure 5: Relative expression of Rab6 and PAP genes. ,
, Figure 3?figure supplement 3. Cdu1 expression in C.
, Figure 10. Localization of PPM1H in RPE cells., MOI=0.2. 20 h after infection the cells were treated with 10 nM nocodazole, and incubated 729 further for 60 min before fixation
, Figure 7?figure supplement 2. miR-223 association with Ago2 in WT and ?YBX1 cells.
, Figure 7?video 1. Loss of GEF-H1, PLC?, or PKD impairs the localized delivery of Rab6-positive vesicles to FAs., TaiP disrupts the ATG16L1-controlled traffic of Rab6-positive vesicles towards 737 TMEM59-positive compartments, vol.5
Tu1854 ATG16L1 Facilitates Bacterial Invasion in Human Cells, Gastroenterology, vol.142, issue.5, pp.S-861, 2012. ,
, Figure 7?video 1. Loss of GEF-H1, PLC?, or PKD impairs the localized delivery of Rab6-positive vesicles to FAs., Rab6 positive veiscles to TMEM59 positive compartments. b. In cells infected with Ctr WT
, Figure 5?source data 1. Expression of wild typeDeoB and ThyA in evolved D27F strain reverts phenotype to high folAmix requirement.
, Figure 5. All discernable domains of SAV1 are required for MST2 activation.
, Figure 8. TLR7 and TLR9 association with UNC93B1 is mutually exclusive., One day later, the cells were lysed, and immunoprecipitation (IP) was performed with anti-HA 746 coupled beads