C. R. Andersson, J. Falsig, J. B. Stavenhagen, S. Christensen, F. Kartberg et al., Antibody-mediated clearance of tau in primary mouse microglial cultures requires Fc?-receptor binding and functional lysosomes, Scientific Reports, vol.9, issue.1, p.4658, 2019.

H. Bourhy, A. Dautry-varsat, P. J. Hotez, and J. Salomon, Rabies, Still Neglected after 125 Years of Vaccination, PLoS Neglected Tropical Diseases, vol.4, issue.11, p.e839, 2010.
URL : https://hal.archives-ouvertes.fr/pasteur-01491946

T. Cantaert, L. Borand, L. Kergoat, C. Leng, S. Ung et al., A 1-week intradermal dose-sparing regimen for rabies post-exposure prophylaxis (RESIST-2): an observational cohort study, The Lancet Infectious Diseases, vol.19, issue.12, pp.1355-1362, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02866747

P. Chauhan, S. Hu, W. S. Sheng, S. Prasad, and J. R. Lokensgard, Modulation of Microglial Cell Fc? Receptor Expression Following Viral Brain Infection, Scientific Reports, vol.7, issue.1, p.41889, 2017.

F. De-chaumont, S. Dallongeville, N. Chenouard, N. Hervé, S. Pop et al., Icy: an open bioimage informatics platform for extended reproducible research, Nature Methods, vol.9, issue.7, pp.690-696, 2012.

J. L. Cohen-pfeffer, S. Gururangan, T. Lester, D. A. Lim, A. J. Shaywitz et al., Intracerebroventricular Delivery as a Safe, Long-Term Route of Drug Administration, Pediatric Neurology, vol.67, pp.23-35, 2017.

E. E. Congdon, J. Gu, H. B. Sait, and E. M. Sigurdsson, Antibody Uptake into Neurons Occurs Primarily via Clathrin-dependent Fc? Receptor Endocytosis and Is a Prerequisite for Acute Tau Protein Clearance, Journal of Biological Chemistry, vol.288, issue.49, pp.35452-35465, 2013.

C. Duma, O. Kopyov, A. Kopyov, M. Berman, E. Lander et al., Human intracerebroventricular (ICV) injection of autologous, non-engineered, adipose-derived stromal vascular fraction (ADSVF) for neurodegenerative disorders: results of a 3-year phase 1 study of 113 injections in 31 patients, Molecular Biology Reports, vol.46, issue.5, pp.5257-5272, 2019.

B. M. Geiger, L. E. Frank, A. D. Caldera-siu, and E. N. Pothos, Survivable Stereotaxic Surgery in Rodents, Journal of Visualized Experiments, vol.20, issue.20, p.880, 2008.

C. W. Gnanadurai, M. Zhou, W. He, C. M. Leyson, C. T. Huang et al., Presence of Virus Neutralizing Antibodies in Cerebral Spinal Fluid Correlates with Non-Lethal Rabies in Dogs, PLoS Neglected Tropical Diseases, vol.7, issue.9, p.e2375, 2013.

N. J. Gogtay, R. Munshi, D. H. Ashwath-narayana, B. J. Mahendra, V. J. Kshirsagar et al., Comparison of a Novel Human Rabies Monoclonal Antibody to Human Rabies Immunoglobulin for Postexposure Prophylaxis: A Phase 2/3, Randomized, Single-Blind, Noninferiority, Controlled Study, Clinical Infectious Diseases, vol.66, issue.3, pp.387-395, 2017.

K. Hampson, L. Coudeville, T. Lembo, M. Sambo, A. Kieffer et al., Estimating the Global Burden of Endemic Canine Rabies, PLOS Neglected Tropical Diseases, vol.9, issue.4, p.e0003709, 2015.

J. Hellert, J. Buchrieser, F. Larrous, A. Minola, G. D. De-melo et al., Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein, Nature Communications, vol.11, issue.1, p.596, 2020.
URL : https://hal.archives-ouvertes.fr/pasteur-02868882

B. Hoffmann, C. M. Freuling, P. R. Wakeley, T. B. Rasmussen, S. Leech et al., Improved Safety for Molecular Diagnosis of Classical Rabies Viruses by Use of a TaqMan Real-Time Reverse Transcription-PCR "Double Check" Strategy, Journal of Clinical Microbiology, vol.48, issue.11, pp.3970-3978, 2010.

D. C. Hooper, T. W. Phares, M. J. Fabis, and A. Roy, The Production of Antibody by Invading B Cells Is Required for the Clearance of Rabies Virus from the Central Nervous System, PLoS Neglected Tropical Diseases, vol.3, issue.10, p.e535, 2009.

C. Huang, Z. Li, Y. Huang, G. Zhang, M. Zhou et al., Enhancement of blood?brain barrier permeability is required for intravenously administered virus neutralizing antibodies to clear an established rabies virus infection from the brain and prevent the development of rabies in mice, Antiviral Research, vol.110, pp.132-141, 2014.

K. W. Huang and B. L. Sabatini, Single-Cell Analysis of Neuroinflammatory Responses Following Intracranial Injection of G-Deleted Rabies Viruses, Frontiers in Cellular Neuroscience, vol.14, p.65, 2020.

M. Hunter, N. Johnson, S. Hedderwick, C. Mccaughey, K. Lowry et al., Immunovirological correlates in human rabies treated with therapeutic coma, Journal of Medical Virology, vol.82, issue.7, pp.1255-1265, 2010.

A. C. Jackson, Rabies: a medical perspective, Revue Scientifique et Technique de l'OIE, vol.37, issue.2, pp.569-580, 2018.

B. J. Jones and D. J. Roberts, The quantitative measurement of motor inco-ordination in naive mice using an accelerating rotarod, Journal of Pharmacy and Pharmacology, vol.20, issue.4, pp.302-304, 1968.

K. Kansagra, D. Parmar, S. K. Mendiratta, J. Patel, S. Joshi et al., A Phase 3, Randomised, Open-Label, Non-Inferiority Trial Evaluating Anti-Rabies Monoclonal Antibody Cocktail (Twinrab <sup>TM</sup>) Against Human Rabies Immunoglobulin (HRIG), SSRN Electronic Journal, 2019.

S. Lê, J. Josse, and F. Husson, FactoMineR: AnRPackage for Multivariate Analysis, Journal of Statistical Software, vol.25, issue.1, p.18, 2008.

M. W. Pfaffl, A new mathematical model for relative quantification in real-time RT-PCR, Nucleic Acids Research, vol.29, issue.9, pp.45e-45, 2001.

Y. Quan, T. Möller, and J. R. Weinstein, Regulation of Fc? receptors and immunoglobulin G-mediated phagocytosis in mouse microglia, Neuroscience Letters, vol.464, issue.1, pp.29-33, 2009.

C. E. Rupprecht, A. R. Fooks, and B. Abela-ridder, Laboratory techniques in rabies, 2018.

K. O. Saunders, Conceptual approaches to modulating antibody effector functions and circulation half-life, Front Immunol, vol.10, p.1296, 2019.

I. Slavc, J. L. Cohen-pfeffer, S. Gururangan, J. Krauser, D. A. Lim et al., Best practices for the use of intracerebroventricular drug delivery devices, Molecular Genetics and Metabolism, vol.124, issue.3, pp.184-188, 2018.

S. P. Smith, G. Wu, A. R. Fooks, J. Ma, and A. C. Banyard, Trying to treat the untreatable: experimental approaches to clear rabies virus infection from the CNS, Journal of General Virology, vol.100, issue.8, pp.1171-1186, 2019.

F. Sonthonnax, B. Besson, E. Bonnaud, G. Jouvion, D. Merino et al., Lyssavirus matrix protein cooperates with phosphoprotein to modulate the Jak-Stat pathway, Scientific Reports, vol.9, issue.1, p.12171, 2019.
URL : https://hal.archives-ouvertes.fr/pasteur-02868844

A. De-souza and S. N. Madhusudana, Survival from rabies encephalitis, Journal of the Neurological Sciences, vol.339, issue.1-2, pp.8-14, 2014.

E. Sparrow, S. Torvaldsen, A. T. Newall, J. G. Wood, M. Sheikh et al., Recent advances in the development of monoclonal antibodies for rabies post exposure prophylaxis: A review of the current status of the clinical development pipeline, Vaccine, vol.37, issue.1, pp.A132-A139, 2019.

S. C. Stanford, The Open Field Test: reinventing the wheel, Journal of Psychopharmacology, vol.21, issue.2, pp.134-135, 2007.

K. Stettler, M. Beltramello, D. A. Espinosa, V. Graham, A. Cassotta et al., Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection, Science, vol.353, issue.6301, pp.823-826, 2016.

A. Tarantola, Four Thousand Years of Concepts Relating to Rabies in Animals and Humans, Its Prevention and Its Cure, Tropical Medicine and Infectious Disease, vol.2, issue.2, p.5, 2017.
URL : https://hal.archives-ouvertes.fr/pasteur-01739365

G. Ugolini and T. Hemachudha, Rabies: changing prophylaxis and new insights in pathophysiology, Curr Opin Infect Dis, vol.31, pp.93-101, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01829659

, Rabies vaccines: WHO position paper, Wkly Epidemiol Rec, vol.93, pp.201-220, 2018.

R. E. Willoughby, K. S. Tieves, G. M. Hoffman, N. S. Ghanayem, C. M. Amlie-lefond et al., Survival after treatment of rabies with induction of coma, N Engl J Med, vol.352, pp.2508-2514, 2005.

F. A. Zeiler and A. C. Jackson, Critical appraisal of the Milwaukee protocol for rabies: this failed approach should be abandoned, Can J Neurol Sci, vol.43, pp.44-51, 2016.