K. Tomczak, P. Czerwi?ska, and M. Wiznerowicz, The Cancer Genome Atlas (TCGA): An immeasurable source of knowledge, Wspolczesna Onkol, vol.1, pp.68-77, 2015.

D. Hanahan and R. A. Weinberg, Hallmarks of cancer: The next generation, Cell, vol.144, pp.646-674, 2011.

L. Martignetti, L. Calzone, E. Bonnet, E. Barillot, A. Zinovyev et al., Representation and quantification of module activity from target expression data, Front. Genet, vol.7, pp.1-12, 2016.

M. Kanehisa, Y. Sato, M. Kawashima, M. Furumichi, and M. Tanabe, KEGG as a reference resource for gene and protein annotation, Nucleic Acids Res, 2016.

A. Fabregat, The Reactome Pathway Knowledgebase, Nucleic Acids Res, 2018.

D. Szklarczyk, STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets, Nucleic Acids Res, vol.47, pp.1-7, 2018.

R. Oughtred, The BioGRID interaction database: 2019 update, Nucleic Acids Res, vol.47, pp.529-541, 2019.

P. Shannon, Cytoscape: a software environment for integrated models of biomolecular interaction networks, Genome Res, vol.13, pp.2498-504, 2003.

M. S. Cline, Integration of biological networks and gene expression data using cytoscape, Nat. Protoc, vol.2, pp.2366-2382, 2007.

S. Lotia, J. Montojo, Y. Dong, G. D. Bader, and A. R. Pico, Cytoscape app store. Bioinformatics, vol.29, pp.1350-1351, 2013.

F. Gwinner, Network-based analysis of omics data: the LEAN method, Bioinformatics, vol.33, pp.701-709, 2017.

F. Bergametti, Mutations within the Programmed Cell Death 10 Gene Cause Cerebral Cavernous Malformations, Am. J. Hum. Genet, 2005.
URL : https://hal.archives-ouvertes.fr/hal-00016902

G. Boulday, Developmental timing of CCM2 loss influences cerebral cavernous malformations 5 in mice, J. Exp. Med, 2011.

J. Loscalzo, A. Barabási, and K. E. Silverman, Network medicine: Complex Systems in Human Disease and Therapeutics, 2017.

J. W. Smoller, Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis, Lancet, vol.381, pp.1371-1379, 2013.

A. J. Rubin, Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks, Cell, vol.176, pp.361-376, 2019.

. Figure and . Left, Cytoscape visualization of a functional subnetwork. Right: Physiological effect discovered by fluorescent