Spatially Modulated Proton Minibeams Results in the Same Increase of Lifespan as a Uniform Target Dose Coverage in F98-Glioma-Bearing Rats.

Charlotte Lamirault (1) , Elise Brisebard (2, 3) , Annalisa Patriarca (4) , Marjorie Juchaux (1) , Delphine Crepin (1) , Dalila Labiod (5, 6) , Frederic Pouzoulet (5, 6) , Catherine Sebrie (7) , Laurene Jourdain (7) , Marine Le Dudal (2, 8, 9) , David Hardy (2) , Ludovic de Marzi (4, 10) , Remi Dendale (4) , Gregory Jouvion (2, 11) , Yolanda Prezado (10)

1 IMNC (UMR_8165) - Imagerie et Modélisation en Neurobiologie et Cancérologie
2 Neuropathologie expérimentale / Experimental neuropathology
3 VAS - VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement
4 Centre de Protonthérapie d'Orsay
5 Plateforme de Radiothérapie Expérimentale
6 Université Paris-Saclay
7 BIOMAPS - LaBoratoire d'Imagerie biOmédicale MultimodAle Paris-Saclay
8 Unité d'Embryologie, d'Histologie et d'Anatomie Pathologique
9 UPEC UP12 - Université Paris-Est Créteil Val-de-Marne - Paris 12
10 Signalisation normale et pathologique de l'embryon aux thérapies innovantes des cancers
11 CHU Trousseau [APHP]

Proton minibeam radiation therapy (pMBRT) is a new approach in proton radiotherapy, by which a significant increase in the therapeutic index has already been demonstrated in RG2 glioma-bearing rats. In the current study we investigated the response of other types of glioma (F98) and performed a comparative evaluation of tumor control effectiveness by pMBRT (with different levels of dose heterogeneity) versus conventional protons. The results of our study showed an equivalent increase in the lifespan for all evaluated groups (conventional proton irradiation and pMBRT) and no significant differences in the histopathological analysis of the tumors or remaining brain tissue. The reduced long-term toxicity observed with pMBRT in previous evaluations at the same dose suggests a possible use of pMBRT to treat glioma with less side effects while ensuring the same tumor control achieved with standard proton therapy.

Domaines: Sciences du Vivant [q-bio]

Charlotte Lamirault, Elise Brisebard, Annalisa Patriarca, Marjorie Juchaux, Delphine Crepin, et al.. Spatially Modulated Proton Minibeams Results in the Same Increase of Lifespan as a Uniform Target Dose Coverage in F98-Glioma-Bearing Rats.. Radiation Research, 2020, 194 (6), pp.715-723. ⟨10.1667/RADE-19-00013.1⟩. ⟨pasteur-02961631⟩