Sumoylation: a regulatory protein modification in health and disease, Annu Rev Biochem, vol.82, pp.357-85, 2013. ,
A comprehensive compilation of SUMO proteomics, Nat Rev Mol Cell Biol, vol.17, pp.581-95, 2016. ,
System-wide changes to SUMO modifications in response to heat shock, Sci Signal, vol.2, p.24, 2009. ,
Control of SUMO and Ubiquitin by ROS: signaling and disease implications, Mol Asp Med, vol.63, pp.3-17, 2018. ,
Regulation of DNA damage responses by ubiquitin and SUMO, Mol Cell, vol.49, pp.795-807, 2013. ,
SUMOylation in carcinogenesis, Cancer Lett, vol.316, pp.113-138, 2012. ,
SUMO and the robustness of cancer, Nat Rev Cancer, vol.17, pp.184-97, 2017. ,
Role of a ubiquitin-conjugating enzyme in degradation of S-and M-phase cyclins, Nature, vol.373, pp.78-81, 1995. ,
Ubc9 is essential for viability of higher eukaryotic cells, Exp Cell Res, vol.280, pp.212-233, 2002. ,
The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice, Dev Cell, vol.9, pp.769-79, 2005. ,
URL : https://hal.archives-ouvertes.fr/pasteur-02075525
Sumoylation at chromatin governs coordinated repression of a transcriptional program essential for cell growth and proliferation, Genome Res, vol.23, pp.1563-79, 2013. ,
Principles of cancer therapy: oncogene and non-oncogene addiction, Cell, vol.136, pp.823-860, 2009. ,
Drugging the addict: nononcogene addiction as a target for cancer therapy, EMBO Rep, vol.17, pp.1516-1547, 2016. ,
A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis, Science, vol.335, pp.348-53, 2012. ,
Oncogenesis driven by the Ras/Raf pathway requires the SUMO E2 ligase Ubc9, Proc Natl Acad Sci, vol.112, pp.1724-1757, 2015. ,
Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor, Nat Chem Biol, vol.13, pp.1164-71, 2017. ,
The intestinal crypt, a prototype stem cell compartment, Cell, vol.154, pp.274-84, 2013. ,
Lessons from hereditary colorectal cancer, Cell, vol.87, pp.159-70, 1996. ,
The chromosomal instability pathway in colon cancer, Gastroenterology, vol.138, pp.2059-72, 2010. ,
Mouse models of intestinal cancer, J Pathol, vol.238, pp.141-51, 2016. ,
Identification of stem cells in small intestine and colon by marker gene Lgr5, Nature, vol.449, pp.1003-1010, 2007. ,
Crypt stem cells as the cells-of-origin of intestinal cancer, Nature, vol.457, pp.608-619, 2009. ,
Sumoylation by Ubc9 regulates the stem cell compartment and structure and function of the intestinal epithelium in mice, Gastroenterology, vol.140, pp.286-96, 2011. ,
URL : https://hal.archives-ouvertes.fr/pasteur-00572277
Focus formation: a cell-based assay to determine the oncogenic potential of a gene, J Vis Exp, 2014. ,
The soft agar colony formation assay, J Vis Exp, 2014. ,
Clonogenic assay: adherent cells, J Vis Exp, 2011. ,
Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas, Proc Natl Acad Sci USA, vol.101, pp.17216-17237, 2004. ,
Tissue-specific and inducible Cre-mediated recombination in the gut epithelium, Genesis, vol.39, pp.186-93, 2004. ,
Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells, Mol Cell Biol, vol.27, pp.7551-7560, 2007. ,
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers, EMBO J, vol.31, pp.3079-91, 2012. ,
Identification of c-MYC as a target of the APC pathway, Science, vol.281, pp.1509-1521, 1998. ,
HOXA5 counteracts stem cell traits by inhibiting Wnt signaling in colorectal cancer, Cancer Cell, vol.28, pp.815-844, 2015. ,
The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas, Differentiation, vol.53, pp.75-93, 1993. ,
Expression analysis of Ubc9, the single small ubiquitin-like modifier (SUMO) E2 conjugating enzyme, in normal and malignant tissues, Hum Pathol, vol.41, pp.1286-98, 2010. ,
GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses, Nucleic Acids Res, vol.45, pp.98-102, 2017. ,
,
, An unanticipated tumor-suppressive role of the SUMO pathway in the intestine unveiled by Ubc9
, inflammatory and anti-viral gene-expression programs during innate sensing, Nat Immunol, vol.17, pp.140-149, 2016.
SUMOylation pathway alteration coupled with downregulation of SUMO E2 enzyme at mucosal epithelium modulates inflammation in inflammatory bowel disease, Open Biol, vol.7, 2017. ,
DeSUMOylase SENP7-mediated epithelial signaling triggers intestinal inflammation via expansion of gamma-delta T cells, Cell Rep, vol.29, pp.3522-3560, 2019. ,
A miR-34a-numb feedforward loop triggered by inflammation regulates asymmetric stem cell division in intestine and colon cancer, Cell Stem Cell, vol.18, pp.189-202, 2016. ,
Interleukin-22 promotes intestinalstem-cell-mediated epithelial regeneration, Nature, vol.528, pp.560-564, 2015. ,
, Immunity, inflammation, and cancer. Cell, vol.140, pp.883-99, 2010.
Reparative inflammation takes charge of tissue regeneration, Nature, vol.529, pp.307-322, 2016. ,
The histone chaperone CAF-1 safeguards somatic cell identity, Nature, vol.528, pp.218-242, 2015. ,
SUMO safeguards somatic and pluripotent cell identities by enforcing distinct chromatin states, Cell Stem Cell, vol.23, pp.742-57, 2018. ,
URL : https://hal.archives-ouvertes.fr/pasteur-02869159
A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable, Nature, vol.478, pp.255-264, 2011. ,
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage, Nat Cell Biol, vol.14, pp.1099-104, 2012. ,
Intestinal label-retaining cells are secretory precursors expressing Lgr5, Nature, vol.495, pp.65-74, 2013. ,
Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele, EMBO J, vol.33, pp.2057-68, 2014. ,
Replacement of lost Lgr5-positive stem cells through plasticity of their enterocyte-lineage daughters, Cell Stem Cell, vol.18, pp.203-216, 2016. ,
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties, Cell, vol.152, pp.25-38, 2013. ,
XRCC3 promotes homology-directed repair of DNA damage in mammalian cells, Genes Dev, vol.13, pp.2633-2641, 1999. ,
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche, Nature, vol.459, pp.262-267, 2009. ,
A framework for oligonucleotide microarray preprocessing, Bioinformatics, vol.26, pp.2363-2370, 2010. ,
limma powers differential expression analyses for RNA-sequencing and microarray studies, Nucleic Acids Res, vol.43, p.47, 2015. ,
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium, Nat Genet, vol.25, pp.25-34, 2000. ,
, The Gene Ontology Consortium. The Gene Ontology resource: 20 years and still GOing strong, Nucleic Acids Res, vol.47, pp.330-338, 2019.
The reactome pathway knowledgebase, Nucleic Acids Res, vol.46, pp.649-55, 2018. ,
KEGG: new perspectives on genomes, pathways, diseases and drugs, Nucleic Acids Res, vol.45, pp.353-61, 2017. ,
KEGG: Kyoto Encyclopedia of Genes and Genomes, Nucleic Acids Res, vol.27, pp.29-34, 1999. ,
Gene set enrichment analysis: a knowledgebased approach for interpreting genome-wide expression profiles, Proc Natl Acad Sci, vol.102, pp.15545-50, 2005. ,
ToppGene Suite for gene list enrichment analysis and candidate gene prioritization, Nucleic Acids Res, vol.37, pp.305-311, 2009. ,