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Epidermodysplasia verruciformis-like eruption complicating human immunodeficiency virus infection

Abstract : Three human immunodeficiency virus (HIV)-infected patients presented with disseminated pityriasis versicolor-like skin lesions. Histological examination showed features characteristic of epidermodysplasia verruciformis (EV). Hybridization studies demonstrated the presence of human papillomavirus (HPV) type 5 (HPV5) DNA in two patients and HPV20 in one. A relative increase in CD8+, CD57+ cells, which are known to inhibit cell-mediated cytolysis, was observed in all patients. HLA-DQB 0301 haplotype, which has been associated with EV, was detected in two patients. The findings suggest that infection with EV-associated HPV types can complicate HIV infection. Both cellular immune defects and a hitherto unknown genetic background might explain the occurrence of EV in HIV-infected patients.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02940308
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Submitted on : Wednesday, September 16, 2020 - 11:19:56 AM
Last modification on : Thursday, October 1, 2020 - 3:25:23 AM

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C. Barzegar, C. Paul, P. Saiag, P. Cassenot, H. Bachelez, et al.. Epidermodysplasia verruciformis-like eruption complicating human immunodeficiency virus infection. British Journal of Dermatology, Wiley, 1998, 139 (1), pp.122-127. ⟨10.1046/j.1365-2133.1998.02328.x⟩. ⟨pasteur-02940308⟩

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