HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Behavioral Sequence Analysis Reveals a Novel Role for ß2* Nicotinic Receptors in Exploration

Abstract : Nicotinic acetylcholine receptors (nAChRs) are widely expressed throughout the central nervous system and modulate neuronal function in most mammalian brain structures. The contribution of defined nAChR subunits to a specific behavior is thus difficult to assess. Mice deleted for beta2-containing nAChRs (beta2-/-) have been shown to be hyperactive in an open-field paradigm, without determining the origin of this hyperactivity. We here develop a quantitative description of mouse behavior in the open field based upon first order Markov and variable length Markov chain analysis focusing on the time-organized sequence that behaviors are composed of. This description reveals that this hyperactivity is the consequence of the absence of specific inactive states or "stops". These stops are associated with a scanning of the environment in wild-type mice (WT), and they affect the way that animals organize their sequence of behaviors when compared with stops without scanning. They characterize a specific "decision moment" that is reduced in beta2-/- mutant mice, suggesting an important role of beta2-nAChRs in the strategy used by animals to explore an environment and collect information in order to organize their behavior. This integrated analysis of the displacement of an animal in a simple environment offers new insights, specifically into the contribution of nAChRs to higher brain functions and more generally into the principles that organize sequences of behaviors in animals.
Document type :
Journal articles
Complete list of metadata

Cited literature [33 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-02935825
Contributor : Rhizlane Laatabi Connect in order to contact the contributor
Submitted on : Thursday, September 10, 2020 - 4:50:50 PM
Last modification on : Thursday, April 7, 2022 - 10:10:28 AM
Long-term archiving on: : Thursday, December 3, 2020 - 2:11:05 AM

File

journal.pcbi.1000229.PDF
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Nicolas Maubourguet, Annick Lesne, Jean-Pierre Changeux, Uwe Maskos, Philippe Faure. Behavioral Sequence Analysis Reveals a Novel Role for ß2* Nicotinic Receptors in Exploration. PLoS Computational Biology, Public Library of Science, 2008, 4 (11), pp.e1000229. ⟨10.1371/journal.pcbi.1000229⟩. ⟨pasteur-02935825⟩

Share

Metrics

Record views

15

Files downloads

37