Nocardia pseudobrasiliensis as an Emerging Cause of Opportunistic Infection after Allogeneic Hematopoietic Stem Cell Transplantation

David Lebeaux (1, 2) , Fanny Lanternier (1, 2, 3) , Nicolas Degand (4) , Emilie Catherinot (5) , Isabelle Podglajen (6, 7) , Marie-Thérèse Rubio (4, 3) , Felipe Suarez (4, 3) , Marc Lecuit (3, 4, 2, 1, 8) , Jean-Luc Mainardi (6, 7) , Olivier Lortholary (1, 9, 3)

1 Centre d'infectiologie Necker-Pasteur [CHU Necker]
2 Service des Maladies infectieuses et tropicales [CHU Necker]
3 UPD5 - Université Paris Descartes - Paris 5
4 CHU Necker - Enfants Malades [AP-HP]
5 Hôpital Foch [Suresnes]
6 HEGP - Hôpital Européen Georges Pompidou [APHP]
7 Laboratoire de Recherche Moléculaire sur les Antibiotiques
8 Equipe avenir - Microorganismes et Barrières de l'Hôte
9 CNRMA - Centre National de Référence des Mycoses invasives et antifongiques - Mycologie moléculaire

We report the case of a 55-year-old man who exhibited a nodular pneumonia 4 months after an allogeneic hematopoietic stem cell transplantation. Culture of the bronchoalveolar lavage fluid revealed Nocardia pseudobrasiliensis. This recently described carbapenem-resistant species should be included in the differential diagnosis of fungal infection in this setting.

Domains: Life Sciences [q-bio]; Human health and pathology; Infectious diseases; Emerging diseases; Microbiology and Parasitology; Bacteriology; Immunology

David Lebeaux, Fanny Lanternier, Nicolas Degand, Emilie Catherinot, Isabelle Podglajen, et al.. Nocardia pseudobrasiliensis as an Emerging Cause of Opportunistic Infection after Allogeneic Hematopoietic Stem Cell Transplantation. Journal of Clinical Microbiology, 2010, 48 (2), pp.656-659. ⟨10.1128/JCM.01244-09⟩. ⟨pasteur-02930892⟩