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Granulocyte Colony Stimulating Factor-induced Exacerbation of Fungus-related Immune Restoration Inflammatory Syndrome: A Case of Chronic Disseminated Candidiasis Exacerbation

Abstract : Chronic disseminated candidiasis is a complication of the intensive therapies of hematological malignancies revealed during hematopoietic recovery, a context reminiscent of the immune restoration inflammatory syndrome in human immunodeficiency virus patients receiving antiretroviral therapy. We report a case of severe exacerbation of chronic disseminated candidiasis after pegylated granulocyte-colony stimulating factor administration. We emphasize the major inflammatory substrate of the disease and suggest that immune-modulating strategies such as hematopoietic growth factors, should be used cautiously in such patients.
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Submitted on : Friday, September 4, 2020 - 1:57:12 PM
Last modification on : Saturday, September 12, 2020 - 3:33:08 AM

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Marie-Olivia Chandesris, Charikleia Kelaidi, Frédéric Méchaï, Marie-Elisabeth Bougnoux, Nicole Brousse, et al.. Granulocyte Colony Stimulating Factor-induced Exacerbation of Fungus-related Immune Restoration Inflammatory Syndrome: A Case of Chronic Disseminated Candidiasis Exacerbation. Journal of Microbiology, Immunology and Infection, Elsevier, 2010, 43 (4), pp.339-343. ⟨10.1016/S1684-1182(10)60052-7⟩. ⟨pasteur-02930417⟩

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