Granulocyte Colony Stimulating Factor-induced Exacerbation of Fungus-related Immune Restoration Inflammatory Syndrome: A Case of Chronic Disseminated Candidiasis Exacerbation

Marie-Olivia Chandesris; Charikleia Kelaidi; Frédéric Méchaï; Marie-Elisabeth Bougnoux; Nicole Brousse; Jean-Paul Viard; Sylvain Poirée; Marc Lecuit; Olivier Hermine; Olivier Lortholary

doi:10.1016/S1684-1182(10)60052-7

Journal articles

Granulocyte Colony Stimulating Factor-induced Exacerbation of Fungus-related Immune Restoration Inflammatory Syndrome: A Case of Chronic Disseminated Candidiasis Exacerbation

Marie-Olivia Chandesris ^{1, 2} Charikleia Kelaidi ^{3, 4} Frédéric Méchaï ^{1, 2} Marie-Elisabeth Bougnoux ^{1, 2} Nicole Brousse ^{1, 2} Jean-Paul Viard ^{1, 2} Sylvain Poirée ¹ Marc Lecuit ^{2, 1, 5} Olivier Hermine ^{1, 2} Olivier Lortholary ^{2, 1}

1 CHU Necker - Enfants Malades [AP-HP]

2 UPD5 - Université Paris Descartes - Paris 5

3 Hôpital Avicenne [AP-HP]

4 UP13 - Université Paris 13

5 Service des Maladies infectieuses et tropicales [CHU Necker]

Abstract : Chronic disseminated candidiasis is a complication of the intensive therapies of hematological malignancies revealed during hematopoietic recovery, a context reminiscent of the immune restoration inflammatory syndrome in human immunodeficiency virus patients receiving antiretroviral therapy. We report a case of severe exacerbation of chronic disseminated candidiasis after pegylated granulocyte-colony stimulating factor administration. We emphasize the major inflammatory substrate of the disease and suggest that immune-modulating strategies such as hematopoietic growth factors, should be used cautiously in such patients.

Keywords : chronic disseminated candidiasis hematopoietic growth factors hepatosplenic candidiasis immune restoration inflammatory syndrome

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Journal articles

Domain :

Life Sciences [q-bio]

Life Sciences [q-bio] / Human health and pathology

Life Sciences [q-bio] / Human health and pathology / Infectious diseases

Life Sciences [q-bio] / Immunology

Life Sciences [q-bio] / Microbiology and Parasitology

Life Sciences [q-bio] / Microbiology and Parasitology / Mycology

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Submitted on : Friday, September 4, 2020 - 1:57:12 PM
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Granulocyte Colony Stimulating Factor-induced Exacerbation of Fungus-related Immune Restoration Inflammatory Syndrome: A Case of Chronic Disseminated Candidiasis Exacerbation

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Granulocyte Colony Stimulating Factor-induced Exacerbation of Fungus-related Immune Restoration Inflammatory Syndrome: A Case of Chronic Disseminated Candidiasis Exacerbation

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