Transversal sero-epidemiological study of Bordetella pertussis in Tehran, Iran

Gaelle Noel (1) , Farzad Badmasti (2) , Vajihe Nikbin (2) , Seyed Zahraei (3) , Yoann Madec (4) , David Tavel (4) , Mohand Ait-Ahmed (5) , Nicole Guiso (1) , Fereshteh Shahcheraghi (2) , Fabien Taieb (1, 4)

1 CRT - Centre de Recherche Translationnelle - Center for Translational Science
2 Institut Pasteur d'Iran
3 Center for Communicable Diseases Control [Iran]
4 Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology
5 PIRC - Pôle Intégré de Recherche Clinique

Pertussis remains endemic despite high vaccine coverage in infants and toddlers. Pertussis vaccines confer protection but immunity wanes overtime and boosters are needed in a lifetime. Iran, eligible for the Expanded Program on Immunization that includes the primary immunization, implemented two additional booster doses using a whole-cell vaccine (wPV) at 18 months-old and about 6 years-old. Duration of protection induced by the wPVs currently in use and their impact as pre-school booster are not well documented. This study aimed at assessing vaccination compliance and at estimating the duration of protection conferred by vaccination with wPV in children aged < 15 years in Tehran, Iran.

Domains: Life Sciences [q-bio]; Immunology; Vaccinology; Life Sciences [q-bio]; Santé publique et épidémiologie

Gaelle Noel, Farzad Badmasti, Vajihe Nikbin, Seyed Zahraei, Yoann Madec, et al.. Transversal sero-epidemiological study of Bordetella pertussis in Tehran, Iran. PLoS ONE, 2020, 15 (9), pp.e0238398. ⟨10.1371/journal.pone.0238398⟩. ⟨pasteur-02929774⟩