Lower Respiratory Tract Infection in a Renal Transplant Recipient: Do not Forget Metapneumovirus

N. Noel (1) , B. Rammaert (1) , J. Zuber (2) , N. Sayre (1) , M. F Mamzer-Bruneel (2) , M. Leruez-Ville (3) , L. Mascard (3) , M. Lecuit (4, 5, 1, 6, 7) , O. Lortholary (8)

1 Service des Maladies infectieuses et tropicales [CHU Necker]
2 Service de néphrologie et transplantation rénale [Hôpital Necker Enfants Malades - APHP]
3 Laboratoire de Microbiologie [AP-HP Necker]
4 UPD5 - Université Paris Descartes - Paris 5
5 Hôpital Necker - Enfants Malades [AP-HP]
6 IMAGINE - U1163 - Imagine - Institut des maladies génétiques
7 Equipe avenir - Microorganismes et Barrières de l'Hôte
8 Centre d'infectiologie Necker-Pasteur [CHU Necker]

Human metapneumovirus (hMPV) is emerging as a cause of a severe respiratory tract infection in immunocompromised patients. hMPV pneumonia has only been seldom reported in nonpulmonary solid organ transplanted patients, such as renal transplant recipients. We report here a case of a 39-year-old patient presenting with fever, cough, and interstitial opacities on CT scan diagnosed as a nonsevere hMPV pneumonia 11 years after a renal transplantation. Infection resolved spontaneously. Differential diagnosis with Pneumocystis pneumonia was discussed. We review the medical literature and discuss clinical presentation and detection methods that can be proposed in solid organ transplant recipients.

Domaines: Sciences du Vivant [q-bio]; Médecine humaine et pathologie; Maladies infectieuses; Microbiologie et Parasitologie; Virologie; Immunologie

N. Noel, B. Rammaert, J. Zuber, N. Sayre, M. F Mamzer-Bruneel, et al.. Lower Respiratory Tract Infection in a Renal Transplant Recipient: Do not Forget Metapneumovirus. Case Reports in Transplantation, 2012, 2012, pp.1-3. ⟨10.1155/2012/353871⟩. ⟨pasteur-02924789⟩