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Les chainons de l’émergence des maladies virales chez l’homme, du passage zoonotique à la transmission interhumaine efficace : les exemples du syndrome respiratoire aigu sévère (SARS) et de la maladie à virus Ebola

Abstract : The entire process of the complete passage of a virus from animals to humans requires five phases. The first one is the unique and short-lived initial zoonotic passage in humans of an animal virus. During the second stage, the animal virus passes more or less often in humans, but inter-human transmission is not possible; man is an epidemiological cul-de-sac. The initial passage to humans can be done directly from the source or by an intermediate animal species. The third phase is reached when, after passing through to humans, the virus undergoes a few cycles of human-to-human transmission that stop quickly. The fourth step is crossed when the chains of human-to-human transmission are extended. When the virus has fully adapted to humans and when its circulation in humans has become permanent and independent of its animal reservoir, the final stage is reached. Here we detail the cases of the emergence of the virus causing the severe acute respiratory syndrome (SARS) and that of the Ebola disease.
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Jean-Claude Manuguerra. Les chainons de l’émergence des maladies virales chez l’homme, du passage zoonotique à la transmission interhumaine efficace : les exemples du syndrome respiratoire aigu sévère (SARS) et de la maladie à virus Ebola. Bulletin de l'Académie Vétérinaire de France, Académie vétérinaire de France, 2020, ⟨10.4267/2042/70854⟩. ⟨pasteur-02917104⟩

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