F. Alfaro-almagro, M. Jenkinson, N. K. Bangerter, L. R. Jesper, L. Andersson et al., Image Processing and Quality Control for the First 10,000 Brain Imaging Datasets from UK Biobank, NeuroImage, vol.166, pp.400-424, 2018.

S. R. Browning and B. L. Browning, Population Structure Can Inflate SNP-Based Heritability Estimates, The American Journal of Human Genetics, vol.89, issue.1, pp.191-93, 2011.

H. D. Daetwyler, B. Villanueva, and J. A. Woolliams, Accuracy of Predicting the Genetic Risk of Disease Using a Genome-Wide Approach, PLOS ONE, vol.3, issue.10, p.3395, 2008.

L. T. Elliott, K. Sharp, F. Alfaro-almagro, S. Shi, K. L. Miller et al., Genome-Wide Association Studies of Brain Imaging Phenotypes in UK Biobank, Nature, vol.562, issue.7726, p.210, 2018.


. Euesden, C. M. Jack, P. F. Lewis, and . O'reilly, PRSice: Polygenic Risk Score Software, Bioinformatics, vol.31, issue.9, pp.1466-68, 2015.

R. Fisher and . Aylmer, Statistical Methods for Research Workers, 1970.

D. P. Hibar, J. L. Stein, M. E. Renteria, A. Arias-vasquez, S. Desrivières et al., Common Genetic Variants Influence Human Subcortical Brain Structures, Nature, vol.520, issue.7546, pp.224-253, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01196805


. Lee, T. R. Hong, S. Decandia, J. Ripke, . Yang et al., Estimating the Proportion of Variation in Susceptibility to Schizophrenia Captured by Common SNPs, Nature Genetics, vol.44, issue.3, pp.247-50, 2012.

. Lee, J. Hong, . Yang, E. Michael, . Goddard et al., Estimation of Pleiotropy between Complex Diseases Using Single-Nucleotide Polymorphism-Derived Genomic Relationships and Restricted Maximum Likelihood, Bioinformatics, vol.28, pp.2540-2582, 2012.


M. Li, G. Santpere, Y. Imamura-kawasawa, O. V. Evgrafov, and O. Forrest,

S. Gulden, S. M. Pochareddy, and . Sunkin, Integrative Functional Genomic Analysis of Human Brain Development and Neuropsychiatric Risks, Science, vol.362, issue.6420, p.7615, 2018.

R. Plomin and I. J. Deary, Genetics and Intelligence Differences: Five Special Findings, Molecular Psychiatry, vol.20, issue.1, pp.98-108, 2015.

E. Ponzi and L. F. Keller, Heritability, Selection, and the Response to Selection in the Presence of Phenotypic Measurement Error: Effects, Cures, and the Role of Repeated Measurements, Timothée Bonnet, and Stefanie Muff, vol.72, pp.1992-2004, 2018.


A. L. Price, E. Michael, N. Weale, S. R. Patterson, and . Myers,

D. Shianna and . Ge, Long-Range LD Can Confound Genome Scans in Admixed Populations, American Journal of Human Genetics, vol.83, issue.1, pp.132-167, 2008.


S. Purcell, B. Neale, K. Todd-brown, L. Thomas, A. R. Manuel et al., PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses, American Journal of Human Genetics, vol.81, issue.3, pp.559-75, 2007.

. Raychaudhuri, J. M. Soumya, S. A. Korn, P. Mccarroll-;-david-altshuler, S. Sklar et al., Accurately Assessing the Risk of Schizophrenia Conferred by Rare Copy-Number Variation Affecting Genes with Brain Function, PLOS Genetics, vol.6, issue.9, p.1001097, 2010.


A. Schoech, D. Jordan, P. Loh, S. Gazal, O. Luke et al., Quantification of Frequency-Dependent Genetic Architectures and Action of Negative Selection in 25 UK Biobank Traits, BioRxiv, 2017.

N. G. Skene, J. Bryois, E. Trygve, G. Bakken, . Breen et al., Genetic Identification of Brain Cell Types Underlying Schizophrenia, Nature Genetics, vol.50, issue.6, pp.825-858, 2018.


J. L. Stein, S. E. Medland, A. A. Vasquez, D. P. Hibar, R. E. Senstad et al., Identification of Common Variants Associated with Human Hippocampal and Intracranial Volumes, Nature Genetics, vol.44, issue.5, pp.552-61, 2012.
URL : https://hal.archives-ouvertes.fr/pasteur-01967151

Y. Taki, H. Hashizume, Y. Sassa, H. Takeuchi, M. Asano et al., Correlation among Body Height, Intelligence, and Brain Gray Matter Volume in Healthy Children, NeuroImage, vol.59, issue.2, pp.1023-1050, 2012.


R. Toro, G. J.-b.-poline, E. Huguet, V. Loth, T. Frouin et al., Genomic Architecture of Human Neuroanatomical Diversity, Molecular Psychiatry, vol.20, issue.8, pp.1011-1027, 2015.
URL : https://hal.archives-ouvertes.fr/pasteur-01967180

P. M. Visscher, G. Hemani, A. A. Vinkhuyzen, G. Chen, S. H. Lee et al., Statistical Power to Detect Genetic (Co)Variance of Complex Traits Using SNP Data in Unrelated Samples, PLoS Genetics, vol.10, issue.4, 2014.

. Wainschtein, D. P. Pierrick, L. Jain, and . Yengo, Zhili Zheng, Trans-Omics for Precision Medicine Consortium TOPMed Anthropometry Working Group, L. Adrienne Cupples

H. Aladdin and . Shadyab, Recovery of Trait Heritability from Whole Genome Sequence Data, BioRxiv, 2019.

N. R. Wray, C. Wijmenga, P. F. Sullivan, J. Yang, and P. M. Visscher, Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model, Cell, vol.173, issue.7, pp.1573-80, 2018.

N. R. Wray, J. Yang, B. J. Hayes, A. L. Price, M. E. Goddard et al.,

. Visscher, Pitfalls of Predicting Complex Traits from SNPs, Nature Reviews Genetics, vol.14, issue.7, pp.507-522, 2013.

J. Yang, A. Bakshi, Z. Zhu, G. Hemani, A. A. Vinkhuyzen et al., Genome-Wide Genetic Homogeneity between Sexes and Populations for Human Height and Body Mass Index, Human Molecular Genetics, vol.24, issue.25, pp.7445-7494, 2015.

J. Yang, B. Benyamin, P. Brian, S. Mcevoy, . Gordon et al., Common SNPs Explain a Large Proportion of the Heritability for Human Height, Nature Genetics, vol.42, issue.7, pp.565-69, 2010.


J. Yang, S. H. Lee, M. E. Goddard, and P. M. Visscher, GCTA: A Tool for Genome-Wide Complex Trait Analysis, The American Journal of Human Genetics, vol.88, issue.1, pp.76-82, 2011.

. Yang, T. A. Jian, L. R. Manolio, E. Pasquale, N. Boerwinkle et al.,

M. Cunningham and . De-andrade, Genome Partitioning of Genetic Variation for Complex Traits Using Common SNPs, Nature Genetics, vol.43, issue.6, pp.519-544, 2011.


L. Yengo, J. Sidorenko, K. E. Kemper, Z. Zheng, A. R. Wood et al.,

T. M. Weedon, J. Frayling, J. Hirschhorn, P. M. Yang, and . Visscher, Meta-Analysis of Genome-Wide Association Studies for Height and Body Mass Index in ?700000 Individuals of European Ancestry, Human Molecular Genetics, vol.27, pp.3641-3690, 1920.

J. Zeng, R. De-vlaming, Y. Wu, M. R. Robinson, L. R. Lloyd-jones et al., Signatures of Negative Selection in the Genetic Architecture of Human Complex Traits, Nature Genetics, vol.50, issue.5, p.746, 2018.


. Zhao, J. G. Bingxin, Y. Ibrahim, T. Li, Y. Li et al., Heritability of Regional Brain Volumes in Large-Scale Neuroimaging and Genetic Studies, Cerebral Cortex, 2018.

. Zuo, J. S. Xi-nian, P. Anderson, . Bellec, M. Rasmus et al.,