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The interplay between innate lymphoid cells and T cells

Abstract : ILCs and T cells are closely related functionally but they significantly differ in their ability to circulate, expand, and renew. Cooperation and reciprocal functional regulation suggest that these cell types are more complementary than simply redundant during immune responses. How ILCs shape T-cell responses is strongly dependent on the tissue and inflammatory context. Likewise, indirect regulation of ILCs by adaptive immunity is induced by environmental cues such as the gut microbiota. Here, we review shared requirements for the development and function of both cell types and divergences in the orchestration of prototypic immune functions. We discuss the diversity of functional interactions between T cells and ILCs during homeostasis and immune responses. Identifying the location and the nature of the tissue microenvironment in which these interactions are taking place may uncover the remaining mysteries of their close encounters.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02910809
Contributor : Marie-Christine Vougny <>
Submitted on : Monday, August 3, 2020 - 10:02:00 AM
Last modification on : Thursday, September 10, 2020 - 10:18:15 AM

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Marie Cherrier, Gayetri Ramachandran, Rachel Golub. The interplay between innate lymphoid cells and T cells. Mucosal Immunology, Nature Pub. Group, 2020, ⟨10.1038/s41385-020-0320-8⟩. ⟨pasteur-02910809⟩

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