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, Deformation maps (average embryos; n = 5 embryos each). B, I, Time evolution of angular positions (average embryos; cf. Fig. 4B). C, J, Tension/viscosity profiles from model fit to average embryos (cf. Fig. 4C). D, Average angular velocity along the margin at t = t 0 + 6.5-7.5 h. E, G, Decomposition of the tissue velocity field into divergent and rotational components (averages over embryos). (K-M) 250 ?m circular laser cuts in a single memGFP embryo (K) and representation of all laser cut experiments (L) for which the response was quantified (M; bars, mean ± SE) (red, Figure S17. Tissue-scale effect of cell division and apoptosis inhibition

, Left: Time-lapse movie of a HU+Q-VD-OPh-treated embryo imaged for 6 h, overlaid with automatically detected margin (dashed line) and apparent forces (arrows), used to position the cuts Right: 250 ?m laser cuts were then sequentially performed in the posterior margin (red square), anterior margin (green square), and EP (blue square). Note the anisotropic relaxation at the margin but not in the EP, Movie S13. Estimation of tissue strain using UV-laser cuts in HU+Q-VD-OPh treated embryos

S. Movie, Top row: schematic of experiment and time-lapse movie of memGFP embryo, overlaid with automatically identified prospective primitive streak (magenta) and EP (green) territories. Middle row: rotational component of the velocity field

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