Skip to Main content Skip to Navigation
Journal articles

A tensile ring drives tissue flows to shape the gastrulating amniote embryo

Abstract : Tissue morphogenesis is driven by local cellular deformations that are powered by contractile actomyosin networks. How localized forces are transmitted across tissues to shape them at a mesoscopic scale is still unclear. Analyzing gastrulation in entire avian embryos, we show that it is driven by the graded contraction of a large-scale supracellular actomyosin ring at the margin between the embryonic and extraembryonic territories. The propagation of these forces is enabled by a fluid-like response of the epithelial embryonic disk, which depends on cell division. A simple model of fluid motion entrained by a tensile ring quantitatively captures the vortex-like "polonaise" movements that accompany the formation of the primitive streak. The geometry of the early embryo thus arises from the transmission of active forces generated along its boundary.
Complete list of metadata

Cited literature [41 references]  Display  Hide  Download
Contributor : Corinne Billion Connect in order to contact the contributor
Submitted on : Thursday, July 23, 2020 - 5:14:17 PM
Last modification on : Friday, August 5, 2022 - 11:58:38 AM
Long-term archiving on: : Tuesday, December 1, 2020 - 7:08:47 PM


Distributed under a Creative Commons Attribution - NonCommercial - ShareAlike 4.0 International License



Mehdi Saadaoui, Didier Rocancourt, Julian Roussel, Francis Corson, Jerome Gros. A tensile ring drives tissue flows to shape the gastrulating amniote embryo. Science, American Association for the Advancement of Science (AAAS), 2020, 367 (6476), pp.453-458. ⟨10.1126/science.aaw1965⟩. ⟨pasteur-02905796⟩



Record views


Files downloads