Interleukin‐22 in urinary tract disease – new experimental directions

Molly A Ingersoll (1) , Malcolm Starkey (2, 3)

1 Inflammation et immunité des muqueuses - Mucosal Inflammation and Immunity
2 Monash Medical Centre [Clayton, Australia]
3 Priority Research Centre GrowUpWell [Australia]

Interleukin (IL)-22 is expressed by immune cells in the urinary tract and IL-22 receptor is expressed in urothelium and renal tubule cells. IL-22 can be specifically targeted in the urinary tract or conditionally depleted in mice and targeted therapeutically in humans.

Domains: Life Sciences [q-bio]; Immunology

Molly A Ingersoll, Malcolm Starkey. Interleukin‐22 in urinary tract disease – new experimental directions. Clinical and Translational Immunology, 2020, 9 (6), pp.e1143. ⟨10.1002/cti2.1143⟩. ⟨pasteur-02899702⟩