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Manipulation of Autophagy by Bacterial Pathogens Impacts Host Immunity
Abstract : Autophagy is a highly conserved catabolic process, degrading unnecessary or damaged components in the eukaryotic cell to maintain cellular homeostasis, but it is also an intrinsic cellular defence mechanism to remove invading pathogens. A crosstalk between autophagy and innate or adaptive immune responses has been recently reported, whereby autophagy influences both, innate and adaptive immunity like the production and secretion of pro-inflammatory cytokines or MHC class II antigen presentation to T cells. Pathogenic bacteria have evolved diverse strategies to manipulate autophagy, mechanisms that also impact host immune responses at different levels. Here we discuss the influence of autophagy on self-autonomous, innate and adaptive immunity and then focus on how bacterial mechanisms that shape autophagy may impact the host immune system.
Cited literature [51 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-02887892
Contributor : Isabelle Hoffmann Connect in order to contact the contributor
Submitted on : Thursday, July 2, 2020 - 3:39:41 PM
Last modification on : Wednesday, June 16, 2021 - 5:26:02 PM
Long-term archiving on: : Thursday, September 24, 2020 - 5:14:07 AM
Contributor : Isabelle Hoffmann Connect in order to contact the contributor
Submitted on : Thursday, July 2, 2020 - 3:39:41 PM
Last modification on : Wednesday, June 16, 2021 - 5:26:02 PM
Long-term archiving on: : Thursday, September 24, 2020 - 5:14:07 AM
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