Assay for Hepatitis B Core-related Antigen Identify Patients With High Viral Load: Systematic Review and Meta-analysis of Individual Participant Data

Kyoko Yoshida (1) , Alice Desbiolles (2) , Sarah Feldman (2) , Sang Hoon Ahn (3) , Enagnon Alidjinou (4, 5) , Masanori Atsukawa (6) , Laurence Bocket (5) , Maurizia Brunetto (7) , Maria Buti (8) , Ivana Carey (9) , Gian Paolo Caviglia (10) , En-Qiang Chen (11) , Markus Cornberg (12) , Masaru Enomoto (13) , Masao Honda (14) , Christoph Höner zu Siederdissen (12) , Masatoshi Ishigami (15) , Harry La Janssen (16) , Benjamin Maasoumy (12) , Takeshi Matsui , Akihiro Matsumoto (17) , Shuhei Nishiguchi (18) , Mar Riveiro-Barciela (8) , Akinobu Takaki (19) , Pisit Tangkijvanich (20) , Hidenori Toyoda , Margo Jh van Campenhout (21) , Bo Wang (9) , Lai Wei (22) , Hwai-I Yang (23) , Yoshihiko Yano (24) , Hiroshi Yatsuhashi , Man-Fung Yuen (25) , Eiji Tanaka (17) , Maud Lemoine (1) , Yasuhito Tanaka (26) , Yusuke Shimakawa (2)

1 Imperial College London
2 Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology
3 Yonsei University
4 Pôle de Biologie Pathologie Génétique [CHU Lille]
5 Laboratoire de Virologie - Laboratoire de Virologie - ULR 3610
6 Chiba University Hospital
7 Azienda Ospedaliera Universitaria Pisana
8 UAB - Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
9 KCH - King's College Hospital
10 UNITO - Università degli studi di Torino = University of Turin
11 SCU - Sichuan University [Chengdu]
12 MHH - Medizinische Hochschule Hannover = Hannover Medical School
13 Graduate School of Medicine [Osaka]
14 KU - Kanazawa University
15 Nagoya University
16 TGHRI - Toronto General Hospital Research Institute [Canada]
17 Shinshu University Hospital
18 University of Hyogo
19 Okayama University
20 Chulalongkorn University [Bangkok]
21 Erasmus MC - Erasmus University Medical Center [Rotterdam]
22 PKUPH - People's Hospital of Peking University
23 Academia Sinica
24 Kobe University
25 HKU - The University of Hong Kong
26 Nagoya City University [Nagoya, Japan]

Scale-up of tests and treatments is needed to eliminate hepatitis B virus (HBV) infection from resource-limited countries. However, access to nucleic acid tests that quantify HBV DNA, to determine treatment eligibility, is severely limited. We performed a systematic review and meta-analysis to assess the performance of the hepatitis B core-related antigen (HBcrAg) immunoassay, a low-cost (less than $15/assay) alternative to the nucleic acid test, to identify highly viremic patients, infected with any HBV genotype.

Mots clés: diagnostic test; real-world; developing nation; diagnosis

Domaines: Santé publique et épidémiologie

Kyoko Yoshida, Alice Desbiolles, Sarah Feldman, Sang Hoon Ahn, Enagnon Alidjinou, et al.. Assay for Hepatitis B Core-related Antigen Identify Patients With High Viral Load: Systematic Review and Meta-analysis of Individual Participant Data. Clinical Gastroenterology and Hepatology, 2020, ⟨10.1016/j.cgh.2020.04.045⟩. ⟨pasteur-02875203⟩