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Assay for Hepatitis B Core-related Antigen Identify Patients With High Viral Load: Systematic Review and Meta-analysis of Individual Participant Data

Kyoko Yoshida 1 Alice Desbiolles 2 Sarah Feldman 2 Sang Hoon Ahn 3 Enagnon Alidjinou 4 Masanori Atsukawa 5 Laurence Bocket 6 Maurizia Brunetto 7 Maria Buti 8 Ivana Carey 9 Gian Paolo Caviglia 10 En-Qiang Chen 11 Markus Cornberg 12 Masaru Enomoto 13 Masao Honda 14 Christoph Höner zu Siederdissen 12 Masatoshi Ishigami 15 Harry La Janssen 16 Benjamin Maasoumy 12 Takeshi Matsui Akihiro Matsumoto 17 Shuhei Nishiguchi 18 Mar Riveiro-Barciela 8 Akinobu Takaki 19 Pisit Tangkijvanich 20 Hidenori Toyoda Margo Jh van Campenhout 21 Bo Wang 9 Lai Wei 22 Hwai-I Yang 23 Yoshihiko Yano 24 Hiroshi Yatsuhashi Man-Fung Yuen 25 Eiji Tanaka 17 Maud Lemoine 1 Yasuhito Tanaka 26 Yusuke Shimakawa 2, *
Abstract : Scale-up of tests and treatments is needed to eliminate hepatitis B virus (HBV) infection from resource-limited countries. However, access to nucleic acid tests that quantify HBV DNA, to determine treatment eligibility, is severely limited. We performed a systematic review and meta-analysis to assess the performance of the hepatitis B core-related antigen (HBcrAg) immunoassay, a low-cost (less than $15/assay) alternative to the nucleic acid test, to identify highly viremic patients, infected with any HBV genotype.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02875203
Contributor : Yusuke Shimakawa <>
Submitted on : Friday, June 19, 2020 - 2:57:54 PM
Last modification on : Thursday, October 8, 2020 - 4:28:05 PM

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Kyoko Yoshida, Alice Desbiolles, Sarah Feldman, Sang Hoon Ahn, Enagnon Alidjinou, et al.. Assay for Hepatitis B Core-related Antigen Identify Patients With High Viral Load: Systematic Review and Meta-analysis of Individual Participant Data. Clinical Gastroenterology and Hepatology, WB Saunders, 2020, ⟨10.1016/j.cgh.2020.04.045⟩. ⟨pasteur-02875203⟩

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