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Synthesis of the methyl glycoside of a branched octasaccharide fragment specific for the Shigella flexneri serotype 2a O-antigen

Abstract : An efficient synthesis of the methyl glycoside of a branched octasaccharide representative of Shigella flexneri serotype 2a O-specific polysaccharide is described. The synthesis is based on the use of the trichloroacetimidate methodology, and involves the condensation of a pentasaccharide acceptor and a trisaccharide donor as the key step. The target octasaccharide was synthesized efficiently according to a strategy based on the condensation of a pentasaccharide acceptor and a trisaccharide donor as the key step.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02875035
Contributor : Armelle Phalipon <>
Submitted on : Friday, June 19, 2020 - 12:54:13 PM
Last modification on : Friday, July 24, 2020 - 3:40:46 AM

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Frédéric Bélot, Corina Costachel, Karen Wright, Armelle Phalipon, Laurence Mulard. Synthesis of the methyl glycoside of a branched octasaccharide fragment specific for the Shigella flexneri serotype 2a O-antigen. Tetrahedron Letters, Elsevier, 2002, 43 (46), pp.8215-8218. ⟨10.1016/S0040-4039(02)02055-5⟩. ⟨pasteur-02875035⟩

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