Pathogen manipulation of B cells: the best defence is a good offence - Institut Pasteur Accéder directement au contenu
Article Dans Une Revue Nature Reviews Microbiology Année : 2015

Pathogen manipulation of B cells: the best defence is a good offence

Résumé

B cells have long been regarded as simple antibody production units, but are now becoming known as key players in both adaptive and innate immune responses. However, several bacteria, viruses and parasites have evolved the ability to manipulate B cell functions to modulate immune responses. Pathogens can affect B cells indirectly, by attacking innate immune cells and altering the cytokine environment, and can also target B cells directly, impairing B cell-mediated immune responses. In this Review, we provide a summary of recent advances in elucidating direct B cell-pathogen interactions and highlight how targeting this specific cell population benefits different pathogens.

Domaines

Bactériologie

Dates et versions

pasteur-02874942 , version 1 (19-06-2020)

Identifiants

Citer

Katharina Nothelfer, Philippe Sansonetti, Armelle Phalipon. Pathogen manipulation of B cells: the best defence is a good offence. Nature Reviews Microbiology, 2015, 13 (3), pp.173-184. ⟨10.1038/nrmicro3415⟩. ⟨pasteur-02874942⟩

Collections

PASTEUR CDF PSL
29 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More