Role of antigen specific T and B cells in systemic and mucosal immune responses in ETEC and Shigella infections, and their potential to serve as correlates of protection in vaccine development

Sachin Mani (1) , Franklin Toapanta (2) , Monica Mcarthur (2) , Firdausi Qadri (3) , Ann-Mari Svennerholm (4) , Bert Devriendt (5) , Armelle Phalipon (6) , Daniel Cohen (7) , Marcelo Sztein (2)

1 PATH [Seattle]
2 University of Maryland School of Medicine
3 ICDDR,B - International Centre for Diarrhoeal Disease Research, Bangladesh
4 GU - University of Gothenburg
5 UGENT - Universiteit Gent = Ghent University
6 Pathogénie microbienne moléculaire
7 Sackler Faculty of Medicine

The generation of robust systemic and mucosal antibody and cell-mediated immune (CMI) responses that are protective, long-lasting, and can quickly be recalled upon subsequent re-exposure to the cognate antigen is the key to the development of effective vaccine candidates. These responses, whether they represent mechanistic or non-mechanistic immunological correlates of protection, usually entail the activation of T cell memory and effector subsets (T-CMI) and induction of long-lasting memory B cells. However, for ETEC and Shigella, the precise role of these key immune cells in primary and secondary (anamnestic) immune responses remains ill-defined. A workshop to address immune correlates for ETEC and Shigella, in general, and to elucidate the mechanistic role of T-cell subsets and B-cells, both systemically and in the mucosal microenvironment, in the development of durable protective immunity against ETEC and Shigella was held at the recent 2nd Vaccines against Shigella and ETEC (VASE) conference in June 2018. This report is a summary of the presentations and the discussion that ensued at the workshop.

Keywords: B cells; Correlates of protection (CoP); Enterotoxigenic Escherichia coli (ETEC); IgA; IgG; Immunocorrelate; Mucosal antibodies; Shigella; T cells

Domains: Bacteriology

Sachin Mani, Franklin Toapanta, Monica Mcarthur, Firdausi Qadri, Ann-Mari Svennerholm, et al.. Role of antigen specific T and B cells in systemic and mucosal immune responses in ETEC and Shigella infections, and their potential to serve as correlates of protection in vaccine development. Vaccine, 2019, 37 (34), pp.4787-4793. ⟨10.1016/j.vaccine.2019.03.040⟩. ⟨pasteur-02874931⟩